de Esch IJ - Search Results

1

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

Stornaiuolo M, De Kloe GE, Rucktooa P, Fish A, van Elk R, Edink ES, Bertrand D, Smit AB, de Esch IJ, Sixma TK. Stornaiuolo M, et al. Among authors: de esch ij, de kloe ge. Nat Commun. 2013;4:1875. doi: 10.1038/ncomms2900. Nat Commun. 2013. PMID: 23695669 Free PMC article.

2

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Ulens C, et al. Among authors: de esch ij. J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g. J Med Chem. 2009. PMID: 19331415

3

Transforming fragments into candidates: small becomes big in medicinal chemistry.

de Kloe GE, Bailey D, Leurs R, de Esch IJ. de Kloe GE, et al. Among authors: de esch ij. Drug Discov Today. 2009 Jul;14(13-14):630-46. doi: 10.1016/j.drudis.2009.03.009. Epub 2009 Mar 31. Drug Discov Today. 2009. PMID: 19443265 Review.

4

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H. Kool J, et al. Among authors: de esch ij, de vlieger js, de kloe ge. J Med Chem. 2010 Jun 24;53(12):4720-30. doi: 10.1021/jm100230k. J Med Chem. 2010. PMID: 20518527

5

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.

Retra K, Geitmann M, Kool J, Smit AB, de Esch IJ, Danielson UH, Irth H. Retra K, et al. Among authors: de esch ij. Anal Biochem. 2010 Dec 1;407(1):58-64. doi: 10.1016/j.ab.2010.06.021. Epub 2010 Jun 17. Anal Biochem. 2010. PMID: 20599657

6

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

Geitmann M, Retra K, de Kloe GE, Homan E, Smit AB, de Esch IJ, Danielson UH. Geitmann M, et al. Among authors: de esch ij, de kloe ge. Biochemistry. 2010 Sep 21;49(37):8143-54. doi: 10.1021/bi1006354. Biochemistry. 2010. PMID: 20701394

7

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ. de Kloe GE, et al. Among authors: de esch ij. J Med Chem. 2010 Oct 14;53(19):7192-201. doi: 10.1021/jm100834y. J Med Chem. 2010. PMID: 20828128

8

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays.

Heus F, Giera M, de Kloe GE, van Iperen D, Buijs J, Nahar TT, Smit AB, Lingeman H, de Esch IJ, Niessen WM, Irth H, Kool J. Heus F, et al. Among authors: de esch ij, de kloe ge. Anal Bioanal Chem. 2010 Dec;398(7-8):3023-32. doi: 10.1007/s00216-010-4210-x. Epub 2010 Sep 25. Anal Bioanal Chem. 2010. PMID: 20872136 Free PMC article.

9

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

Kool J, de Kloe G, Denker AD, van Altena K, Smoluch M, van Iperen D, Nahar TT, Limburg RJ, Niessen WM, Lingeman H, Leurs R, de Esch IJ, Smit AB, Irth H. Kool J, et al. Among authors: de esch ij, de kloe g. Anal Chem. 2011 Jan 1;83(1):125-32. doi: 10.1021/ac102001g. Epub 2010 Nov 30. Anal Chem. 2011. PMID: 21117623

10

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Edink E, Rucktooa P, Retra K, Akdemir A, Nahar T, Zuiderveld O, van Elk R, Janssen E, van Nierop P, van Muijlwijk-Koezen J, Smit AB, Sixma TK, Leurs R, de Esch IJ. Edink E, et al. Among authors: de esch ij. J Am Chem Soc. 2011 Apr 13;133(14):5363-71. doi: 10.1021/ja110571r. Epub 2011 Feb 15. J Am Chem Soc. 2011. PMID: 21322593

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