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C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, Fleet GW. Jenkinson SF, et al. Among authors: wilson fx. J Org Chem. 2013 Aug 2;78(15):7380-97. doi: 10.1021/jo4005487. Epub 2013 Jun 5. J Org Chem. 2013. PMID: 23688199
Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.
Glawar AF, Best D, Ayers BJ, Miyauchi S, Nakagawa S, Aguilar-Moncayo M, García Fernández JM, Ortiz Mellet C, Crabtree EV, Butters TD, Wilson FX, Kato A, Fleet GW. Glawar AF, et al. Among authors: wilson fx. Chemistry. 2012 Jul 23;18(30):9341-59. doi: 10.1002/chem.201200110. Epub 2012 Jun 26. Chemistry. 2012. PMID: 22736508
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ, Martínez RF, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ. Vuorinen A, et al. Among authors: wilson fx. Eur J Med Chem. 2021 Aug 5;220:113431. doi: 10.1016/j.ejmech.2021.113431. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33915371
1-De-oxy-1-fluoro-l-galactitol.
Jenkinson SF, Best D, Izumori K, Wilson FX, Weymouth-Wilson AC, Fleet GW, Thompson AL. Jenkinson SF, et al. Among authors: wilson fx. Acta Crystallogr Sect E Struct Rep Online. 2010 May 12;66(Pt 6):o1330. doi: 10.1107/S1600536810016624. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579420 Free PMC article.
6-De-oxy-6-fluoro-d-galactose.
Jenkinson SF, Best D, Izumori K, Wilson FX, Weymouth-Wilson AC, Fleet GW, Thompson AL. Jenkinson SF, et al. Among authors: wilson fx. Acta Crystallogr Sect E Struct Rep Online. 2010 May 12;66(Pt 6):o1315. doi: 10.1107/S1600536810016612. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579408 Free PMC article.
(4R)-4-(2-Allyl-2H-1,2,3-triazol-4-yl)-1,2-O-isopropyl-idene-l-threose.
Jenkinson SF, Best D, Wilson FX, Fleet GW, Watkin DJ. Jenkinson SF, et al. Among authors: wilson fx. Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 13;64(Pt 12):o2361. doi: 10.1107/S1600536808036416. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21581334 Free PMC article.
38 results