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C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, Fleet GW. Jenkinson SF, et al. Among authors: best d. J Org Chem. 2013 Aug 2;78(15):7380-97. doi: 10.1021/jo4005487. Epub 2013 Jun 5. J Org Chem. 2013. PMID: 23688199
Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.
Glawar AF, Best D, Ayers BJ, Miyauchi S, Nakagawa S, Aguilar-Moncayo M, García Fernández JM, Ortiz Mellet C, Crabtree EV, Butters TD, Wilson FX, Kato A, Fleet GW. Glawar AF, et al. Among authors: best d. Chemistry. 2012 Jul 23;18(30):9341-59. doi: 10.1002/chem.201200110. Epub 2012 Jun 26. Chemistry. 2012. PMID: 22736508
1-De-oxy-1-fluoro-l-galactitol.
Jenkinson SF, Best D, Izumori K, Wilson FX, Weymouth-Wilson AC, Fleet GW, Thompson AL. Jenkinson SF, et al. Among authors: best d. Acta Crystallogr Sect E Struct Rep Online. 2010 May 12;66(Pt 6):o1330. doi: 10.1107/S1600536810016624. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579420 Free PMC article.
6-De-oxy-6-fluoro-d-galactose.
Jenkinson SF, Best D, Izumori K, Wilson FX, Weymouth-Wilson AC, Fleet GW, Thompson AL. Jenkinson SF, et al. Among authors: best d. Acta Crystallogr Sect E Struct Rep Online. 2010 May 12;66(Pt 6):o1315. doi: 10.1107/S1600536810016612. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579408 Free PMC article.
(4R)-4-(2-Allyl-2H-1,2,3-triazol-4-yl)-1,2-O-isopropyl-idene-l-threose.
Jenkinson SF, Best D, Wilson FX, Fleet GW, Watkin DJ. Jenkinson SF, et al. Among authors: best d. Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 13;64(Pt 12):o2361. doi: 10.1107/S1600536808036416. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21581334 Free PMC article.
(1S)-1,2-O-Benzyl-idene-α-d-glucurono-6,3-lactone.
Jenkinson SF, Best D, Weymouth-Wilson AC, Clarkson RA, Fleet GW, Watkin DJ. Jenkinson SF, et al. Among authors: best d. Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 31;65(Pt 2):o414-5. doi: 10.1107/S1600536809002876. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21582005 Free PMC article.
tert-Butyl 2-de-oxy-4,5-O-isopropyl-idene-d-gluconate.
Jenkinson SF, Booth KV, Best D, Fleet GW, Watkin DJ. Jenkinson SF, et al. Among authors: best d. Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 27;64(Pt 10):o2011-2. doi: 10.1107/S160053680803064X. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21201208 Free PMC article.
Pharmacological chaperones for human α-N-acetylgalactosaminidase.
Clark NE, Metcalf MC, Best D, Fleet GW, Garman SC. Clark NE, et al. Among authors: best d. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17400-5. doi: 10.1073/pnas.1203924109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045655 Free PMC article.
516 results