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C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, Fleet GW. Jenkinson SF, et al. Among authors: becq f. J Org Chem. 2013 Aug 2;78(15):7380-97. doi: 10.1021/jo4005487. Epub 2013 Jun 5. J Org Chem. 2013. PMID: 23688199
4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.
da Cruz FP, Newberry S, Jenkinson SF, Wormald MR, Butters TD, Alonzi DS, Nakagawa S, Becq F, Norez C, Nash RJ, Kato A, Fleet GW. da Cruz FP, et al. Among authors: becq f. Tetrahedron Lett. 2011 Jan 12;52(2):219-223. doi: 10.1016/j.tetlet.2010.10.173. Tetrahedron Lett. 2011. PMID: 21157573 Free PMC article.
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.
Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y. Désiré J, et al. Among authors: becq f. Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j. Org Biomol Chem. 2014. PMID: 25277226
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.
Cendret V, Legigan T, Mingot A, Thibaudeau S, Adachi I, Forcella M, Parenti P, Bertrand J, Becq F, Norez C, Désiré J, Kato A, Blériot Y. Cendret V, et al. Among authors: becq f. Org Biomol Chem. 2015 Nov 21;13(43):10734-44. doi: 10.1039/c5ob01526j. Org Biomol Chem. 2015. PMID: 26356422 Free article.
Anti-inflammatory effect of miglustat in bronchial epithelial cells.
Dechecchi MC, Nicolis E, Norez C, Bezzerri V, Borgatti M, Mancini I, Rizzotti P, Ribeiro CM, Gambari R, Becq F, Cabrini G. Dechecchi MC, et al. Among authors: becq f. J Cyst Fibros. 2008 Nov;7(6):555-65. doi: 10.1016/j.jcf.2008.06.002. Epub 2008 Sep 23. J Cyst Fibros. 2008. PMID: 18815075 Free article.
137 results