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Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
J Med Chem. 2013 Jun 27;56(12):5094-114. doi: 10.1021/jm400459m. Epub 2013 Jun 6.
J Med Chem. 2013.
PMID: 23678871
Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration.
Sparks SM, Spearing PK, Diaz CJ, Cowan DJ, Jayawickreme C, Chen G, Rimele TJ, Generaux C, Harston LT, Roller SG.
Sparks SM, et al. Among authors: harston lt.
Bioorg Med Chem Lett. 2017 Oct 15;27(20):4673-4677. doi: 10.1016/j.bmcl.2017.09.008. Epub 2017 Sep 7.
Bioorg Med Chem Lett. 2017.
PMID: 28916340
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Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration.
Sparks SM, Zhou H, Generaux C, Harston L, Moncol D, Jayawickreme C, Parham J, Condreay P, Rimele T.
Sparks SM, et al.
Bioorg Med Chem Lett. 2016 Apr 15;26(8):1901-4. doi: 10.1016/j.bmcl.2016.03.025. Epub 2016 Mar 9.
Bioorg Med Chem Lett. 2016.
PMID: 26988301
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