Feldman PL - Search Results

1

Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.

Wu Y, Aquino CJ, Cowan DJ, Anderson DL, Ambroso JL, Bishop MJ, Boros EE, Chen L, Cunningham A, Dobbins RL, Feldman PL, Harston LT, Kaldor IW, Klein R, Liang X, McIntyre MS, Merrill CL, Patterson KM, Prescott JS, Ray JS, Roller SG, Yao X, Young A, Yuen J, Collins JL. Wu Y, et al. Among authors: feldman pl. J Med Chem. 2013 Jun 27;56(12):5094-114. doi: 10.1021/jm400459m. Epub 2013 Jun 6. J Med Chem. 2013. PMID: 23678871

2

6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist.

Tavares FX, Al-Barazanji KA, Bishop MJ, Britt CS, Carlton DL, Cooper JP, Feldman PL, Garrido DM, Goetz AS, Grizzle MK, Hertzog DL, Ignar DM, Lang DG, McIntyre MS, Ott RJ, Peat AJ, Zhou HQ. Tavares FX, et al. Among authors: feldman pl. J Med Chem. 2006 Nov 30;49(24):7108-18. doi: 10.1021/jm060814b. J Med Chem. 2006. PMID: 17125263

3

Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists.

Pacofsky GJ, Stafford JA, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Kaldor I, Koszalka GW, Lovell GG, McIntyre MS, Tidwell JH, Todd D, Whitesell G, Wiard RP, Feldman PL. Pacofsky GJ, et al. Among authors: feldman pl. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3219-22. doi: 10.1016/s0960-894x(02)00513-9. Bioorg Med Chem Lett. 2002. PMID: 12372538

4

Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.

Boros EE, Samano V, Ray JA, Thompson JB, Jung DK, Kaldor I, Koble CS, Martin MT, Styles VL, Mook RA Jr, Feldman PL, Savarese JJ, Belmont MR, Bigham EC, Boswell GE, Hashim MA, Patel SS, Wisowaty JC, Bowers GD, Moseley CL, Walsh JS, Reese MJ, Rutkowske RD, Sefler AM, Spitzer TD. Boros EE, et al. Among authors: feldman pl. J Med Chem. 2003 Jun 5;46(12):2502-15. doi: 10.1021/jm020574+. J Med Chem. 2003. PMID: 12773054

5

Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1.

Tavares FX, Al-Barazanji KA, Bigham EC, Bishop MJ, Britt CS, Carlton DL, Feldman PL, Goetz AS, Grizzle MK, Guo YC, Handlon AL, Hertzog DL, Ignar DM, Lang DG, Ott RJ, Peat AJ, Zhou HQ. Tavares FX, et al. Among authors: feldman pl. J Med Chem. 2006 Nov 30;49(24):7095-107. doi: 10.1021/jm060572f. J Med Chem. 2006. PMID: 17125262

6

Phosphodiesterase type IV inhibition. Structure-activity relationships of 1,3-disubstituted pyrrolidines.

Feldman PL, Brackeen MF, Cowan DJ, Marron BE, Schoenen FJ, Stafford JA, Suh EM, Domanico PL, Rose D, Leesnitzer MA, et al. Feldman PL, et al. J Med Chem. 1995 Apr 28;38(9):1505-10. doi: 10.1021/jm00009a011. J Med Chem. 1995. PMID: 7739009

7

Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers.

Boros EE, Bigham EC, Boswell GE, Mook RA Jr, Patel SS, Savarese JJ, Ray JA, Thompson JB, Hashim MA, Wisowaty JC, Feldman PL, Samano V. Boros EE, et al. Among authors: feldman pl. J Med Chem. 1999 Jan 28;42(2):206-9. doi: 10.1021/jm980597h. J Med Chem. 1999. PMID: 9925724 No abstract available.

8

Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists.

Stafford JA, Pacofsky GJ, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Jung DK, Koszalka GW, McIntyre MS, Tidwell JH, Wiard RP, Feldman PL. Stafford JA, et al. Among authors: feldman pl. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3215-8. doi: 10.1016/s0960-894x(02)00512-7. Bioorg Med Chem Lett. 2002. PMID: 12372537

9

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

Brackeen MF, Cowan DJ, Stafford JA, Schoenen FJ, Veal JM, Domanico PL, Rose D, Strickland AB, Verghese M, Feldman PL. Brackeen MF, et al. Among authors: feldman pl. J Med Chem. 1995 Nov 24;38(24):4848-54. doi: 10.1021/jm00024a012. J Med Chem. 1995. PMID: 7490734

10

Stereocontrolled synthesis of cis-dibenzoquinolizine chlorofumarates: curare-like agents of ultrashort duration.

Kaldor I, Feldman PL, Mook RA Jr, Ray JA, Samano V, Sefler AM, Thompson JB, Travis BR, Boros EE. Kaldor I, et al. Among authors: feldman pl. J Org Chem. 2001 May 18;66(10):3495-501. doi: 10.1021/jo010032k. J Org Chem. 2001. PMID: 11348135

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