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Programmable DNA-binding small molecules.
Blackledge MS, Melander C. Blackledge MS, et al. Bioorg Med Chem. 2013 Oct 15;21(20):6101-14. doi: 10.1016/j.bmc.2013.04.023. Epub 2013 Apr 18. Bioorg Med Chem. 2013. PMID: 23665141 Free PMC article. Review.
The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.
Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C. Nguyen TV, et al. Among authors: blackledge ms. Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3940-3944. doi: 10.1002/anie.201612006. Epub 2017 Mar 1. Angew Chem Int Ed Engl. 2017. PMID: 28247991 Free PMC article.
2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.
Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ. Jeon AB, et al. Among authors: blackledge ms. PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017. PLoS One. 2017. PMID: 28749949 Free PMC article.
18 results