Schleicher E - Search Results

1

Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation.

Neukamm SS, Ott J, Dammeier S, Lehmann R, Häring HU, Schleicher E, Weigert C. Neukamm SS, et al. Among authors: schleicher e. J Biol Chem. 2013 Jun 7;288(23):16403-16415. doi: 10.1074/jbc.M113.474593. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615913 Free PMC article.

2

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

Hennige AM, Stefan N, Kapp K, Lehmann R, Weigert C, Beck A, Moeschel K, Mushack J, Schleicher E, Häring HU. Hennige AM, et al. Among authors: schleicher e. FASEB J. 2006 Jun;20(8):1206-8. doi: 10.1096/fj.05-4635fje. Epub 2006 Apr 12. FASEB J. 2006. PMID: 16611834

3

Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells.

Weigert C, Kron M, Kalbacher H, Pohl AK, Runge H, Häring HU, Schleicher E, Lehmann R. Weigert C, et al. Among authors: schleicher e. Mol Endocrinol. 2008 Dec;22(12):2729-40. doi: 10.1210/me.2008-0102. Epub 2008 Oct 16. Mol Endocrinol. 2008. PMID: 18927238 Free PMC article.

4

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.

Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Häring HU, Lehmann R. Moeschel K, et al. J Biol Chem. 2004 Jun 11;279(24):25157-63. doi: 10.1074/jbc.M402477200. Epub 2004 Apr 5. J Biol Chem. 2004. PMID: 15069075 Free article.

5

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.

Müssig K, Fiedler H, Staiger H, Weigert C, Lehmann R, Schleicher ED, Häring HU. Müssig K, et al. Biochem Biophys Res Commun. 2005 Sep 30;335(3):819-25. doi: 10.1016/j.bbrc.2005.07.154. Biochem Biophys Res Commun. 2005. PMID: 16099431

6

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.

Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R. Weigert C, et al. J Biol Chem. 2005 Nov 11;280(45):37393-9. doi: 10.1074/jbc.M506134200. Epub 2005 Aug 29. J Biol Chem. 2005. PMID: 16129678 Free article.

7

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.

Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED. Weigert C, et al. J Biol Chem. 2006 Mar 17;281(11):7060-7. doi: 10.1074/jbc.M509782200. Epub 2006 Jan 17. J Biol Chem. 2006. PMID: 16418171 Free article.

8

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.

Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R. Waraich RS, et al. J Biol Chem. 2008 Apr 25;283(17):11226-33. doi: 10.1074/jbc.M708588200. Epub 2008 Feb 19. J Biol Chem. 2008. PMID: 18285345 Free article.

9

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907.

Fritsche L, Neukamm SS, Lehmann R, Kremmer E, Hennige AM, Hunder-Gugel A, Schenk M, Häring HU, Schleicher ED, Weigert C. Fritsche L, et al. Among authors: schleicher ed. Am J Physiol Endocrinol Metab. 2011 May;300(5):E824-36. doi: 10.1152/ajpendo.00409.2010. Epub 2010 Nov 23. Am J Physiol Endocrinol Metab. 2011. PMID: 21098738 Free article.

10

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573.

Neukamm SS, Toth R, Morrice N, Campbell DG, Mackintosh C, Lehmann R, Haering HU, Schleicher ED, Weigert C. Neukamm SS, et al. PLoS One. 2012;7(8):e43296. doi: 10.1371/journal.pone.0043296. Epub 2012 Aug 17. PLoS One. 2012. PMID: 22912850 Free PMC article.

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