Mitsuya H - Search Results

1

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: mitsuya h. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.

2

Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.

Koh Y, Matsumi S, Das D, Amano M, Davis DA, Li J, Leschenko S, Baldridge A, Shioda T, Yarchoan R, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: mitsuya h. J Biol Chem. 2007 Sep 28;282(39):28709-28720. doi: 10.1074/jbc.M703938200. Epub 2007 Jul 17. J Biol Chem. 2007. PMID: 17635930 Free article.

3

P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.

Fujimoto H, Higuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H. Fujimoto H, et al. Among authors: mitsuya h. Biol Pharm Bull. 2009 Sep;32(9):1588-93. doi: 10.1248/bpb.32.1588. Biol Pharm Bull. 2009. PMID: 19721237 Free PMC article.

4

Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.

Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: mitsuya h. J Med Chem. 2009 Dec 10;52(23):7689-705. doi: 10.1021/jm900695w. J Med Chem. 2009. PMID: 19746963 Free PMC article.

5

Prediction of potency of protease inhibitors using free energy simulations with polarizable quantum mechanics-based ligand charges and a hybrid water model.

Das D, Koh Y, Tojo Y, Ghosh AK, Mitsuya H. Das D, et al. Among authors: mitsuya h. J Chem Inf Model. 2009 Dec;49(12):2851-62. doi: 10.1021/ci900320p. J Chem Inf Model. 2009. PMID: 19928916 Free PMC article.

6

Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation.

Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H. Ghosh AK, et al. Among authors: mitsuya h. J Med Chem. 2011 Jan 27;54(2):622-34. doi: 10.1021/jm1012787. Epub 2010 Dec 31. J Med Chem. 2011. PMID: 21194227 Free PMC article.

7

Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition.

Amano M, Bulut H, Tamiya S, Nakamura T, Koh Y, Mitsuya H. Amano M, et al. Among authors: mitsuya h. Sci Rep. 2019 Jul 8;9(1):9806. doi: 10.1038/s41598-019-46082-2. Sci Rep. 2019. PMID: 31285456 Free PMC article.

8

Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Tamamura H, et al. Among authors: mitsuya h. J Med Chem. 2003 Apr 24;46(9):1764-8. doi: 10.1021/jm020537i. J Med Chem. 2003. PMID: 12699395

9

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.

Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: mitsuya h. J Med Chem. 2006 Aug 24;49(17):5252-61. doi: 10.1021/jm060561m. J Med Chem. 2006. PMID: 16913714

10

Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors.

Aoki M, Venzon DJ, Koh Y, Aoki-Ogata H, Miyakawa T, Yoshimura K, Maeda K, Mitsuya H. Aoki M, et al. Among authors: mitsuya h. J Virol. 2009 Apr;83(7):3059-68. doi: 10.1128/JVI.02539-08. Epub 2009 Jan 28. J Virol. 2009. PMID: 19176623 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

710 results

Search Page