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The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: jena n. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Kessl JJ, et al. Among authors: jena n. J Biol Chem. 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21. J Biol Chem. 2012. PMID: 22437836 Free PMC article.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. Among authors: jena n. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.
The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. Slaughter A, et al. Among authors: jena n. Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. Retrovirology. 2014. PMID: 25421939 Free PMC article.
Indole-based allosteric inhibitors of HIV-1 integrase.
Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Patel PA, et al. Among authors: jena n. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4748-4752. doi: 10.1016/j.bmcl.2016.08.037. Epub 2016 Aug 13. Bioorg Med Chem Lett. 2016. PMID: 27568085 Free PMC article.
Bioactive flavaglines and other constituents isolated from Aglaia perviridis.
Pan L, Acuña UM, Li J, Jena N, Ninh TN, Pannell CM, Chai H, Fuchs JR, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. Pan L, et al. Among authors: jena n. J Nat Prod. 2013 Mar 22;76(3):394-404. doi: 10.1021/np3007588. Epub 2013 Jan 9. J Nat Prod. 2013. PMID: 23301897 Free PMC article.
Inactivation of Bcl-2 by phosphorylation.
Haldar S, Jena N, Croce CM. Haldar S, et al. Among authors: jena n. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4507-11. doi: 10.1073/pnas.92.10.4507. Proc Natl Acad Sci U S A. 1995. PMID: 7753834 Free PMC article.
Purification and characterization of the bcl-2 protein.
Haldar S, Jena N, DuBois GC, Takayama S, Reed JC, Fu SS, Croce CM. Haldar S, et al. Among authors: jena n. Arch Biochem Biophys. 1994 Dec;315(2):483-8. doi: 10.1006/abbi.1994.1529. Arch Biochem Biophys. 1994. PMID: 7986096
143 results