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The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: engelman a. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.
Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb A. Zamborlini A, et al. Among authors: engelman a. J Biol Chem. 2011 Jun 10;286(23):21013-22. doi: 10.1074/jbc.M110.189274. Epub 2011 Mar 21. J Biol Chem. 2011. PMID: 21454548 Free PMC article.
243 results