Mikuni J - Search Results

1

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.

Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y, Wakiyama M, Uchida N, Tomizawa-Murasawa M, Kaneko A, Tanaka S, Suzuki N, Kajita H, Aoki Y, Ohara O, Shultz LD, Fukami T, Goto T, Taniguchi S, Yokoyama S, Ishikawa F. Saito Y, et al. Among authors: mikuni j. Sci Transl Med. 2013 Apr 17;5(181):181ra52. doi: 10.1126/scitranslmed.3004387. Sci Transl Med. 2013. PMID: 23596204

2

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T. Yuki H, et al. Among authors: mikuni j. Bioorg Med Chem. 2017 Aug 15;25(16):4259-4264. doi: 10.1016/j.bmc.2017.05.053. Epub 2017 Jun 16. Bioorg Med Chem. 2017. PMID: 28662963

3

Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.

Parker LJ, Taruya S, Tsuganezawa K, Ogawa N, Mikuni J, Honda K, Tomabechi Y, Handa N, Shirouzu M, Yokoyama S, Tanaka A. Parker LJ, et al. Among authors: mikuni j. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):392-404. doi: 10.1107/S1399004713028654. Epub 2014 Jan 29. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24531473

4

Crystal structures of the S6K1 kinase domain in complexes with inhibitors.

Niwa H, Mikuni J, Sasaki S, Tomabechi Y, Honda K, Ikeda M, Ohsawa N, Wakiyama M, Handa N, Shirouzu M, Honma T, Tanaka A, Yokoyama S. Niwa H, et al. Among authors: mikuni j. J Struct Funct Genomics. 2014 Sep;15(3):153-64. doi: 10.1007/s10969-014-9188-8. Epub 2014 Jul 31. J Struct Funct Genomics. 2014. PMID: 25078151 Free PMC article.

5

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.

Koda Y, Kikuzato K, Mikuni J, Tanaka A, Yuki H, Honma T, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Shirai F, Koyama H. Koda Y, et al. Among authors: mikuni j. Bioorg Med Chem Lett. 2017 Nov 15;27(22):4994-4998. doi: 10.1016/j.bmcl.2017.10.012. Epub 2017 Oct 7. Bioorg Med Chem Lett. 2017. PMID: 29037944

6

Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.

Takaya D, Niwa H, Mikuni J, Nakamura K, Handa N, Tanaka A, Yokoyama S, Honma T. Takaya D, et al. Among authors: mikuni j. J Mol Graph Model. 2020 Sep;99:107599. doi: 10.1016/j.jmgm.2020.107599. Epub 2020 Apr 10. J Mol Graph Model. 2020. PMID: 32348940

7

Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.

Katsura K, Tomabechi Y, Matsuda T, Yonemochi M, Mikuni J, Ohsawa N, Terada T, Yokoyama S, Kukimoto-Niino M, Takemoto C, Shirouzu M. Katsura K, et al. Among authors: mikuni j. Protein Expr Purif. 2018 Oct;150:92-99. doi: 10.1016/j.pep.2018.05.005. Epub 2018 May 21. Protein Expr Purif. 2018. PMID: 29793032

8

Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.

Sato T, Watanabe H, Tsuganezawa K, Yuki H, Mikuni J, Yoshikawa S, Kukimoto-Niino M, Fujimoto T, Terazawa Y, Wakiyama M, Kojima H, Okabe T, Nagano T, Shirouzu M, Yokoyama S, Tanaka A, Honma T. Sato T, et al. Among authors: mikuni j. Bioorg Med Chem. 2012 Jun 15;20(12):3756-67. doi: 10.1016/j.bmc.2012.04.042. Epub 2012 Apr 27. Bioorg Med Chem. 2012. PMID: 22607878

9

A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors.

Mikuni J, Kato M, Taruya S, Tsuganezawa K, Mori M, Ogawa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A. Mikuni J, et al. Anal Biochem. 2010 Jul 1;402(1):26-31. doi: 10.1016/j.ab.2010.03.019. Epub 2010 Mar 15. Anal Biochem. 2010. PMID: 20298671

10

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.

Shimizu H, Saito A, Mikuni J, Nakayama EE, Koyama H, Honma T, Shirouzu M, Sekine SI, Shioda T. Shimizu H, et al. Among authors: mikuni j. PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007894. doi: 10.1371/journal.pntd.0007894. eCollection 2019 Nov. PLoS Negl Trop Dis. 2019. PMID: 31738758 Free PMC article.

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