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A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB. van Vugt MA, et al. Among authors: smerdon sj. PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287. PLoS Biol. 2010. PMID: 20126263 Free PMC article.
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.
Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB. Alexander J, et al. Among authors: smerdon sj. Sci Signal. 2011 Jun 28;4(179):ra42. doi: 10.1126/scisignal.2001796. Sci Signal. 2011. PMID: 21712545 Free PMC article.
The FHA domain in DNA repair and checkpoint signaling.
Durocher D, Smerdon SJ, Yaffe MB, Jackson SP. Durocher D, et al. Among authors: smerdon sj. Cold Spring Harb Symp Quant Biol. 2000;65:423-31. doi: 10.1101/sqb.2000.65.423. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760058 Review. No abstract available.
99 results