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Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells.
PLoS One. 2013;8(4):e60020. doi: 10.1371/journal.pone.0060020. Epub 2013 Apr 3.
PLoS One. 2013.
PMID: 23573229
Free PMC article.
Chromatin repressive complexes in stem cells, development, and cancer.
Laugesen A, Helin K.
Laugesen A, et al.
Cell Stem Cell. 2014 Jun 5;14(6):735-51. doi: 10.1016/j.stem.2014.05.006.
Cell Stem Cell. 2014.
PMID: 24905164
Free article.
Review.
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The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.
Pedersen MT, Agger K, Laugesen A, Johansen JV, Cloos PA, Christensen J, Helin K.
Pedersen MT, et al. Among authors: laugesen a.
Mol Cell Biol. 2014 Mar;34(6):1031-45. doi: 10.1128/MCB.00864-13. Epub 2014 Jan 6.
Mol Cell Biol. 2014.
PMID: 24396064
Free PMC article.
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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.
Pedersen MT, Kooistra SM, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K, Helin K.
Pedersen MT, et al. Among authors: laugesen a.
EMBO J. 2016 Jul 15;35(14):1550-64. doi: 10.15252/embj.201593317. Epub 2016 Jun 6.
EMBO J. 2016.
PMID: 27266524
Free PMC article.
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Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.
Laugesen A, Højfeldt JW, Helin K.
Laugesen A, et al.
Cold Spring Harb Perspect Med. 2016 Sep 1;6(9):a026575. doi: 10.1101/cshperspect.a026575.
Cold Spring Harb Perspect Med. 2016.
PMID: 27449971
Free PMC article.
Review.
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Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K.
Højfeldt JW, et al. Among authors: laugesen a.
Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26.
Nat Struct Mol Biol. 2018.
PMID: 29483650
Free PMC article.
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Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.
Laugesen A, Højfeldt JW, Helin K.
Laugesen A, et al.
Mol Cell. 2019 Apr 4;74(1):8-18. doi: 10.1016/j.molcel.2019.03.011.
Mol Cell. 2019.
PMID: 30951652
Free PMC article.
Review.
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Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity.
Højfeldt JW, Hedehus L, Laugesen A, Tatar T, Wiehle L, Helin K.
Højfeldt JW, et al. Among authors: laugesen a.
Mol Cell. 2019 Nov 7;76(3):423-436.e3. doi: 10.1016/j.molcel.2019.07.031. Epub 2019 Sep 11.
Mol Cell. 2019.
PMID: 31521506
Free PMC article.
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