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AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M. Eriksson A, et al. Among authors: kultima hg. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. Biochem Pharmacol. 2014. PMID: 24200998 Free article. Clinical Trial.
Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines.
Sooman L, Ekman S, Andersson C, Kultima HG, Isaksson A, Johansson F, Bergqvist M, Blomquist E, Lennartsson J, Gullbo J. Sooman L, et al. Among authors: kultima hg. Cancer Chemother Pharmacol. 2013 Aug;72(2):329-40. doi: 10.1007/s00280-013-2197-7. Epub 2013 Jun 5. Cancer Chemother Pharmacol. 2013. PMID: 23736154
Targeted resequencing of candidate genes using selector probes.
Johansson H, Isaksson M, Sörqvist EF, Roos F, Stenberg J, Sjöblom T, Botling J, Micke P, Edlund K, Fredriksson S, Kultima HG, Ericsson O, Nilsson M. Johansson H, et al. Among authors: kultima hg. Nucleic Acids Res. 2011 Jan;39(2):e8. doi: 10.1093/nar/gkq1005. Epub 2010 Nov 8. Nucleic Acids Res. 2011. PMID: 21059679 Free PMC article.
Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer.
Micke P, Edlund K, Holmberg L, Kultima HG, Mansouri L, Ekman S, Bergqvist M, Scheibenflug L, Lamberg K, Myrdal G, Berglund A, Andersson A, Lambe M, Nyberg F, Thomas A, Isaksson A, Botling J. Micke P, et al. Among authors: kultima hg. J Thorac Oncol. 2011 Nov;6(11):1833-40. doi: 10.1097/JTO.0b013e3182295917. J Thorac Oncol. 2011. PMID: 22011649 Free article.
Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.
Mengelbier LH, Karlsson J, Lindgren D, Valind A, Lilljebjörn H, Jansson C, Bexell D, Braekeveldt N, Ameur A, Jonson T, Kultima HG, Isaksson A, Asmundsson J, Versteeg R, Rissler M, Fioretos T, Sandstedt B, Börjesson A, Backman T, Pal N, Øra I, Mayrhofer M, Gisselsson D. Mengelbier LH, et al. Among authors: kultima hg. Nat Commun. 2015 Jan 27;6:6125. doi: 10.1038/ncomms7125. Nat Commun. 2015. PMID: 25625758 Free article.
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