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mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.
Decuypere JP, Kindt D, Luyten T, Welkenhuyzen K, Missiaen L, De Smedt H, Bultynck G, Parys JB. Decuypere JP, et al. Among authors: welkenhuyzen k. PLoS One. 2013;8(4):e61020. doi: 10.1371/journal.pone.0061020. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565295 Free PMC article.
IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.
Akl H, Monaco G, La Rovere R, Welkenhuyzen K, Kiviluoto S, Vervliet T, Molgó J, Distelhorst CW, Missiaen L, Mikoshiba K, Parys JB, De Smedt H, Bultynck G. Akl H, et al. Among authors: welkenhuyzen k. Cell Death Dis. 2013 May 16;4(5):e632. doi: 10.1038/cddis.2013.140. Cell Death Dis. 2013. PMID: 23681227 Free PMC article.
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis.
Kiviluoto S, Luyten T, Schneider L, Lisak D, Rojas-Rivera D, Welkenhuyzen K, Missaen L, De Smedt H, Parys JB, Hetz C, Methner A, Bultynck G. Kiviluoto S, et al. Among authors: welkenhuyzen k. Cell Calcium. 2013 Sep;54(3):186-92. doi: 10.1016/j.ceca.2013.06.002. Epub 2013 Jul 16. Cell Calcium. 2013. PMID: 23867001
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
Mekahli D, Decuypere JP, Sammels E, Welkenhuyzen K, Schoeber J, Audrezet MP, Corvelyn A, Dechênes G, Ong AC, Wilmer MJ, van den Heuvel L, Bultynck G, Parys JB, Missiaen L, Levtchenko E, De Smedt H. Mekahli D, et al. Among authors: welkenhuyzen k. Pflugers Arch. 2014 Aug;466(8):1591-604. doi: 10.1007/s00424-013-1394-x. Epub 2013 Nov 6. Pflugers Arch. 2014. PMID: 24193408
The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.
Ivanova H, Ritaine A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G. Ivanova H, et al. Among authors: welkenhuyzen k. Oncotarget. 2016 Aug 23;7(34):55704-55720. doi: 10.18632/oncotarget.11005. Oncotarget. 2016. PMID: 27494888 Free PMC article.
21 results