Cance WG - Search Results

1

Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics.

Cance WG, Kurenova E, Marlowe T, Golubovskaya V. Cance WG, et al. Sci Signal. 2013 Mar 26;6(268):pe10. doi: 10.1126/scisignal.2004021. Sci Signal. 2013. PMID: 23532331 Free PMC article. Review.

2

Focal adhesion kinase and p53 signaling in cancer cells.

Golubovskaya VM, Cance WG. Golubovskaya VM, et al. Among authors: cance wg. Int Rev Cytol. 2007;263:103-53. doi: 10.1016/S0074-7696(07)63003-4. Int Rev Cytol. 2007. PMID: 17725966 Review.

3

Focal adhesion kinase versus p53: apoptosis or survival?

Cance WG, Golubovskaya VM. Cance WG, et al. Sci Signal. 2008 May 20;1(20):pe22. doi: 10.1126/stke.120pe22. Sci Signal. 2008. PMID: 18493017 Free PMC article. Review.

4

Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase.

Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Kweh F, et al. Among authors: cance wg. Mol Carcinog. 2009 Nov;48(11):1005-17. doi: 10.1002/mc.20552. Mol Carcinog. 2009. PMID: 19479903 Free PMC article.

5

Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.

Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG. Kurenova EV, et al. Among authors: cance wg. J Med Chem. 2009 Aug 13;52(15):4716-24. doi: 10.1021/jm900159g. J Med Chem. 2009. PMID: 19610651 Free PMC article.

6

The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.

Golubovskaya VM, Zheng M, Zhang L, Li JL, Cance WG. Golubovskaya VM, et al. Among authors: cance wg. BMC Cancer. 2009 Aug 12;9:280. doi: 10.1186/1471-2407-9-280. BMC Cancer. 2009. PMID: 19671193 Free PMC article.

7

FAK and p53 protein interactions.

Golubovskaya VM, Cance WG. Golubovskaya VM, et al. Among authors: cance wg. Anticancer Agents Med Chem. 2011 Sep;11(7):617-9. doi: 10.2174/187152011796817619. Anticancer Agents Med Chem. 2011. PMID: 21355845 Free PMC article. Review.

8

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.

Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG. Golubovskaya VM, et al. Among authors: cance wg. Carcinogenesis. 2012 May;33(5):1004-13. doi: 10.1093/carcin/bgs120. Epub 2012 Mar 7. Carcinogenesis. 2012. PMID: 22402131 Free PMC article.

9

Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.

Ho B, Olson G, Figel S, Gelman I, Cance WG, Golubovskaya VM. Ho B, et al. Among authors: cance wg. J Biol Chem. 2012 May 25;287(22):18656-73. doi: 10.1074/jbc.M111.322883. Epub 2012 Apr 5. J Biol Chem. 2012. PMID: 22493428 Free PMC article.

10

MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.

Golubovskaya VM, Sumbler B, Ho B, Yemma M, Cance WG. Golubovskaya VM, et al. Among authors: cance wg. Anticancer Agents Med Chem. 2014 Jan;14(1):18-28. doi: 10.2174/187152061401140108113435. Anticancer Agents Med Chem. 2014. PMID: 23438844 Free PMC article.

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