Hopkins SC - Search Results

1

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21. J Pharmacol Exp Ther. 2013. PMID: 23520265 Free article.

2

In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry.

Hopkins SC, Brian Nofsinger J, Allen MS, Koch P, Varney MA. Hopkins SC, et al. Biopharm Drug Dispos. 2009 Jan;30(1):9-20. doi: 10.1002/bdd.641. Biopharm Drug Dispos. 2009. PMID: 19152227

3

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH. Hopkins SC, et al. J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30. J Med Chem. 2013. PMID: 23631755

4

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.

Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1. Pharmacol Res Perspect. 2013. PMID: 25505561 Free PMC article.

5

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action.

Dedic N, Jones PG, Hopkins SC, Lew R, Shao L, Campbell JE, Spear KL, Large TH, Campbell UC, Hanania T, Leahy E, Koblan KS. Dedic N, et al. Among authors: hopkins sc. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. doi: 10.1124/jpet.119.260281. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371483

6

Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats.

Synan C, Bowen C, Heal DJ, Froger-Colléaux C, Beardsley PM, Dedic N, Hopkins SC, Campbell U, Koblan KS. Synan C, et al. Among authors: hopkins sc. Drug Alcohol Depend. 2022 Feb 1;231:109261. doi: 10.1016/j.drugalcdep.2021.109261. Epub 2021 Dec 31. Drug Alcohol Depend. 2022. PMID: 35033729 Free article.

7

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.

Heffernan MLR, Herman LW, Brown S, Jones PG, Shao L, Hewitt MC, Campbell JE, Dedic N, Hopkins SC, Koblan KS, Xie L. Heffernan MLR, et al. Among authors: hopkins sc. ACS Med Chem Lett. 2021 Dec 6;13(1):92-98. doi: 10.1021/acsmedchemlett.1c00527. eCollection 2022 Jan 13. ACS Med Chem Lett. 2021. PMID: 35047111 Free PMC article.

8

Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.

Hopkins SC, Wilkinson S, Corriveau TJ, Nishikawa H, Nakamichi K, Loebel A, Koblan KS. Hopkins SC, et al. Clin Pharmacol Ther. 2021 Sep;110(3):808-815. doi: 10.1002/cpt.2282. Epub 2021 Jun 12. Clin Pharmacol Ther. 2021. PMID: 33961287 Free PMC article. Clinical Trial.

9

Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures.

Sunkaraneni S, Ludwig E, Fiedler-Kelly J, Hopkins S, Galluppi G, Blum D. Sunkaraneni S, et al. J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):649-658. doi: 10.1007/s10928-018-9596-7. Epub 2018 Jun 9. J Pharmacokinet Pharmacodyn. 2018. PMID: 29948795 Free PMC article.

10

Pharmacokinetics and Exposure-Response Relationships of Dasotraline in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults.

Hopkins SC, Sunkaraneni S, Skende E, Hing J, Passarell JA, Loebel A, Koblan KS. Hopkins SC, et al. Clin Drug Investig. 2016 Feb;36(2):137-46. doi: 10.1007/s40261-015-0358-7. Clin Drug Investig. 2016. PMID: 26597180 Free PMC article.

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