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Page 1
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21.
J Pharmacol Exp Ther. 2013.
PMID: 23520265
Free article.
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH.
Hopkins SC, et al. Among authors: heffernan ml.
J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30.
J Med Chem. 2013.
PMID: 23631755
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Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.
Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH.
Hopkins SC, et al. Among authors: heffernan ml.
Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1.
Pharmacol Res Perspect. 2013.
PMID: 25505561
Free PMC article.
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Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Terry-Lorenzo RT, Chun LE, Brown SP, Heffernan ML, Fang QK, Orsini MA, Pollegioni L, Hardy LW, Spear KL, Large TH.
Terry-Lorenzo RT, et al. Among authors: heffernan ml.
Biosci Rep. 2014 Aug 11;34(4):e00133. doi: 10.1042/BSR20140071.
Biosci Rep. 2014.
PMID: 25001371
Free PMC article.
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Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.
Heffernan MLR, Herman LW, Brown S, Jones PG, Shao L, Hewitt MC, Campbell JE, Dedic N, Hopkins SC, Koblan KS, Xie L.
Heffernan MLR, et al.
ACS Med Chem Lett. 2021 Dec 6;13(1):92-98. doi: 10.1021/acsmedchemlett.1c00527. eCollection 2022 Jan 13.
ACS Med Chem Lett. 2021.
PMID: 35047111
Free PMC article.
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Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial.
Pieske B, Wachter R, Shah SJ, Baldridge A, Szeczoedy P, Ibram G, Shi V, Zhao Z, Cowie MR; PARALLAX Investigators and Committee members.
Pieske B, et al.
JAMA. 2021 Nov 16;326(19):1919-1929. doi: 10.1001/jama.2021.18463.
JAMA. 2021.
PMID: 34783839
Free PMC article.
Clinical Trial.
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Empagliflozin in Heart Failure with a Preserved Ejection Fraction.
Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators.
Anker SD, et al.
N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
N Engl J Med. 2021.
PMID: 34449189
Clinical Trial.
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