Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity.
Budziñski ML, Sokn C, Gobbini R, Ugo B, Antunica-Noguerol M, Senin S, Bajaj T, Gassen NC, Rein T, Schmidt MV, Binder EB, Arzt E, Liberman AC.
Budziñski ML, et al. Among authors: rein t.
Mol Psychiatry. 2022 May;27(5):2533-2545. doi: 10.1038/s41380-022-01491-0. Epub 2022 Mar 8.
Mol Psychiatry. 2022.
PMID: 35256747