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Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).
Metzger F, Sajid W, Saenger S, Staudenmaier C, van der Poel C, Sobottka B, Schuler A, Sawitzky M, Poirier R, Tuerck D, Schick E, Schaubmar A, Hesse F, Amrein K, Loetscher H, Lynch GS, Hoeflich A, De Meyts P, Schoenfeld HJ. Metzger F, et al. Among authors: hoeflich a. J Biol Chem. 2011 Jun 3;286(22):19501-10. doi: 10.1074/jbc.M110.172189. Epub 2011 Apr 1. J Biol Chem. 2011. PMID: 21460230 Free PMC article.
Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice.
Sawitzky M, Zeissler A, Langhammer M, Bielohuby M, Stock P, Hammon HM, Görs S, Metges CC, Stoehr BJ, Bidlingmaier M, Fromm-Dornieden C, Baumgartner BG, Christ B, Brenig B, Binder G, Metzger F, Renne U, Hoeflich A. Sawitzky M, et al. Among authors: hoeflich a. PLoS One. 2012;7(6):e39711. doi: 10.1371/journal.pone.0039711. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768110 Free PMC article.
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Saenger S, Holtmann B, Nilges MR, Schroeder S, Hoeflich A, Kletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M, Metzger F. Saenger S, et al. Among authors: hoeflich a. Amyotroph Lateral Scler. 2012 Sep;13(5):418-29. doi: 10.3109/17482968.2012.679944. Epub 2012 Aug 7. Amyotroph Lateral Scler. 2012. PMID: 22871074
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.
Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E. Hoeflich A, et al. Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28. Aging Cell. 2016. PMID: 26507795 Free PMC article.
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.
Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS. Swiderski K, et al. Among authors: hoeflich a. Growth Horm IGF Res. 2016 Oct-Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29. Growth Horm IGF Res. 2016. PMID: 27544574
168 results