Segrestaa J - Search Results

1

Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line.

Fahrmayr C, König J, Auge D, Mieth M, Münch K, Segrestaa J, Pfeifer T, Treiber A, Fromm M. Fahrmayr C, et al. Among authors: segrestaa j. Br J Pharmacol. 2013 May;169(1):21-33. doi: 10.1111/bph.12126. Br J Pharmacol. 2013. PMID: 23387445 Free PMC article.

2

Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.

de Kanter R, Sidharta PN, Delahaye S, Gnerre C, Segrestaa J, Buchmann S, Kohl C, Treiber A. de Kanter R, et al. Among authors: segrestaa j. Clin Pharmacokinet. 2016 Mar;55(3):369-80. doi: 10.1007/s40262-015-0322-y. Clin Pharmacokinet. 2016. PMID: 26385839

3

The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog.

Treiber A, Miraval T, Bolli MH, Funel JA, Segrestaa J, Seeland S. Treiber A, et al. Among authors: segrestaa j. Xenobiotica. 2016;46(3):253-67. doi: 10.3109/00498254.2015.1070302. Epub 2015 Sep 4. Xenobiotica. 2016. PMID: 26337830

4

The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.

Gnerre C, Segrestaa J, Seeland S, Äänismaa P, Pfeifer T, Delahaye S, de Kanter R, Ichikawa T, Yamada T, Treiber A. Gnerre C, et al. Among authors: segrestaa j. Xenobiotica. 2018 Jul;48(7):704-719. doi: 10.1080/00498254.2017.1357088. Epub 2017 Aug 30. Xenobiotica. 2018. PMID: 28737453 Clinical Trial.

5

Cross-species comparison of the metabolism and excretion of selexipag.

Ichikawa T, Yamada T, Treiber A, Gnerre C, Segrestaa J, Seeland S, Nonaka K. Ichikawa T, et al. Among authors: segrestaa j. Xenobiotica. 2019 Mar;49(3):284-301. doi: 10.1080/00498254.2018.1444814. Epub 2018 Mar 21. Xenobiotica. 2019. PMID: 29468921

6

Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects.

Kaufmann P, Niglis S, Bruderer S, Segrestaa J, Äänismaa P, Halabi A, Dingemanse J. Kaufmann P, et al. Among authors: segrestaa j. Br J Clin Pharmacol. 2015 Oct;80(4):670-7. doi: 10.1111/bcp.12650. Epub 2015 Jun 12. Br J Clin Pharmacol. 2015. PMID: 25851691 Free PMC article. Clinical Trial.

7

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968).

Risch P, Pfeifer T, Segrestaa J, Fretz H, Pothier J. Risch P, et al. Among authors: segrestaa j. J Med Chem. 2015 Oct 22;58(20):8011-35. doi: 10.1021/acs.jmedchem.5b00824. Epub 2015 Oct 2. J Med Chem. 2015. PMID: 26398218

8

Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data.

Huynh C, Seeland S, Segrestaa J, Gnerre C, Hogeback J, Meyer Zu Schwabedissen HE, Dingemanse J, Sidharta PN. Huynh C, et al. Among authors: segrestaa j. Front Pharmacol. 2022 Mar 30;13:812065. doi: 10.3389/fphar.2022.812065. eCollection 2022. Front Pharmacol. 2022. PMID: 35431953 Free PMC article.

9

Changes in indocyanine green kinetics after the administration of enalapril to healthy subjects.

Geneve J, Le Dinh T, Brouard A, Bails M, Segrestaa JM, Caulin C. Geneve J, et al. Among authors: segrestaa jm. Br J Clin Pharmacol. 1990 Aug;30(2):297-300. doi: 10.1111/j.1365-2125.1990.tb03779.x. Br J Clin Pharmacol. 1990. PMID: 2206792 Free PMC article.

10

Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.

Welford RW, Vercauteren M, Trébaul A, Cattaneo C, Eckert D, Garzotti M, Sieber P, Segrestaa J, Studer R, Groenen PM, Nayler O. Welford RW, et al. Among authors: segrestaa j. Sci Rep. 2016 Jul 21;6:30059. doi: 10.1038/srep30059. Sci Rep. 2016. PMID: 27444653 Free PMC article.

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