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Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Ann Hum Genet. 2013 Mar;77(2):85-105. doi: 10.1111/ahg.12000. Epub 2013 Jan 30.
Ann Hum Genet. 2013.
PMID: 23360175
Free PMC article.
Complement receptor 1 (CR1) and Alzheimer's disease.
Crehan H, Holton P, Wray S, Pocock J, Guerreiro R, Hardy J.
Crehan H, et al.
Immunobiology. 2012 Feb;217(2):244-50. doi: 10.1016/j.imbio.2011.07.017. Epub 2011 Jul 23.
Immunobiology. 2012.
PMID: 21840620
Review.
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Microglia, Alzheimer's disease, and complement.
Crehan H, Hardy J, Pocock J.
Crehan H, et al.
Int J Alzheimers Dis. 2012;2012:983640. doi: 10.1155/2012/983640. Epub 2012 Aug 21.
Int J Alzheimers Dis. 2012.
PMID: 22957298
Free PMC article.
Item in Clipboard
Blockage of CR1 prevents activation of rodent microglia.
Crehan H, Hardy J, Pocock J.
Crehan H, et al.
Neurobiol Dis. 2013 Jun;54:139-49. doi: 10.1016/j.nbd.2013.02.003. Epub 2013 Feb 27.
Neurobiol Dis. 2013.
PMID: 23454195
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Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.
Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA.
Crehan H, et al.
Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8.
Alzheimers Res Ther. 2020.
PMID: 31931873
Free PMC article.
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Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges.
Cynis H, Frost JL, Crehan H, Lemere CA.
Cynis H, et al. Among authors: crehan h.
Mol Neurodegener. 2016 Jun 30;11(1):48. doi: 10.1186/s13024-016-0115-2.
Mol Neurodegener. 2016.
PMID: 27363697
Free PMC article.
Review.
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