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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.
Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Bock F, et al. Among authors: pelicci pg. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. Epub 2012 Dec 24. Proc Natl Acad Sci U S A. 2013. PMID: 23267072 Free PMC article.
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P. Napoli C, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. doi: 10.1073/pnas.0336359100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571362 Free PMC article.
Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes.
Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B. Shahzad K, et al. Among authors: pelicci pg. Commun Biol. 2018 Aug 6;1:104. doi: 10.1038/s42003-018-0108-5. eCollection 2018. Commun Biol. 2018. PMID: 30271984 Free PMC article.
P66Shc signals to age.
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M. Trinei M, et al. Aging (Albany NY). 2009 Jun 5;1(6):503-10. doi: 10.18632/aging.100057. Aging (Albany NY). 2009. PMID: 20157533 Free PMC article. Review.
542 results