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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M. Yu W, et al. Among authors: iacob re. Nat Commun. 2012;3:1288. doi: 10.1038/ncomms2304. Nat Commun. 2012. PMID: 23250418 Free article.
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Zhou W, et al. Among authors: iacob re. Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622. Nature. 2009. PMID: 20033049 Free PMC article.
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Zhang J, et al. Among authors: iacob re. Nature. 2010 Jan 28;463(7280):501-6. doi: 10.1038/nature08675. Epub 2010 Jan 13. Nature. 2010. PMID: 20072125 Free PMC article.
Structure and dynamic regulation of Abl kinases.
Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE. Panjarian S, et al. Among authors: iacob re. J Biol Chem. 2013 Feb 22;288(8):5443-50. doi: 10.1074/jbc.R112.438382. Epub 2013 Jan 11. J Biol Chem. 2013. PMID: 23316053 Free PMC article. Review.
Electron transfer control in soluble methane monooxygenase.
Wang W, Iacob RE, Luoh RP, Engen JR, Lippard SJ. Wang W, et al. Among authors: iacob re. J Am Chem Soc. 2014 Jul 9;136(27):9754-62. doi: 10.1021/ja504688z. Epub 2014 Jun 24. J Am Chem Soc. 2014. PMID: 24937475 Free PMC article.
Applications of hydrogen/deuterium exchange MS from 2012 to 2014.
Pirrone GF, Iacob RE, Engen JR. Pirrone GF, et al. Among authors: iacob re. Anal Chem. 2015 Jan 6;87(1):99-118. doi: 10.1021/ac5040242. Epub 2014 Nov 14. Anal Chem. 2015. PMID: 25398026 Free PMC article. Review. No abstract available.
44 results