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Synthesis and evaluation of α-thymidine analogues as novel antimalarials.
Cui H, Carrero-Lérida J, Silva AP, Whittingham JL, Brannigan JA, Ruiz-Pérez LM, Read KD, Wilson KS, González-Pacanowska D, Gilbert IH. Cui H, et al. Among authors: brannigan ja. J Med Chem. 2012 Dec 27;55(24):10948-57. doi: 10.1021/jm301328h. Epub 2012 Dec 14. J Med Chem. 2012. PMID: 23240776 Free PMC article.
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Hampton SE, Baragaña B, Schipani A, Bosch-Navarrete C, Musso-Buendía JA, Recio E, Kaiser M, Whittingham JL, Roberts SM, Shevtsov M, Brannigan JA, Kahnberg P, Brun R, Wilson KS, González-Pacanowska D, Johansson NG, Gilbert IH. Hampton SE, et al. Among authors: brannigan ja. ChemMedChem. 2011 Oct 4;6(10):1816-31. doi: 10.1002/cmdc.201100255. ChemMedChem. 2011. PMID: 22049550
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. Frearson JA, et al. Among authors: brannigan ja. Nature. 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893. Nature. 2010. PMID: 20360736 Free PMC article.
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.
Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS. Grenha R, et al. Among authors: brannigan ja. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):459-62. doi: 10.1107/S174430910501095X. Epub 2005 Apr 9. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511068 Free PMC article.
Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile.
Whittingham JL, Hanai S, Brannigan JA, Ferreira WT, Dodson EJ, Turkenburg JP, Cartwright J, Cutting SM, Wilkinson AJ. Whittingham JL, et al. Among authors: brannigan ja. Acta Crystallogr F Struct Biol Commun. 2020 Jun 1;76(Pt 6):241-249. doi: 10.1107/S2053230X20006147. Epub 2020 May 29. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32510464 Free PMC article.
Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.
Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Bell AS, et al. Among authors: brannigan ja. J Med Chem. 2020 Jul 23;63(14):7740-7765. doi: 10.1021/acs.jmedchem.0c00570. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32575985 Free PMC article.
115 results