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Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target.
Treger RS, Cook AG, Rai G, Maloney DJ, Simeonov A, Jadhav A, Thomas CJ, Williams DL, Cappello M, Vermeire JJ. Treger RS, et al. Among authors: vermeire jj. Int J Parasitol Drugs Drug Resist. 2012 Dec 1;2:171-177. doi: 10.1016/j.ijpddr.2012.05.001. Epub 2012 May 18. Int J Parasitol Drugs Drug Resist. 2012. PMID: 22844653 Free PMC article.
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