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Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.
Redecke L, Nass K, DePonte DP, White TA, Rehders D, Barty A, Stellato F, Liang M, Barends TRM, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Aquila A, Arnlund D, Bajt S, Barth T, Bogan MJ, Caleman C, Chao TC, Doak RB, Fleckenstein H, Frank M, Fromme R, Galli L, Grotjohann I, Hunter MS, Johansson LC, Kassemeyer S, Katona G, Kirian RA, Koopmann R, Kupitz C, Lomb L, Martin AV, Mogk S, Neutze R, Shoeman RL, Steinbrener J, Timneanu N, Wang D, Weierstall U, Zatsepin NA, Spence JCH, Fromme P, Schlichting I, Duszenko M, Betzel C, Chapman HN. Redecke L, et al. Among authors: mogk s. Science. 2013 Jan 11;339(6116):227-230. doi: 10.1126/science.1229663. Epub 2012 Nov 29. Science. 2013. PMID: 23196907 Free PMC article.
In vivo protein crystallization in combination with highly brilliant radiation sources offers novel opportunities for the structural analysis of post-translationally modified eukaryotic proteins.
Duszenko M, Redecke L, Mudogo CN, Sommer BP, Mogk S, Oberthuer D, Betzel C. Duszenko M, et al. Among authors: mogk s. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):929-37. doi: 10.1107/S2053230X15011450. Epub 2015 Jul 29. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26249677 Free PMC article. Review.
Serial crystallography on in vivo grown microcrystals using synchrotron radiation.
Gati C, Bourenkov G, Klinge M, Rehders D, Stellato F, Oberthür D, Yefanov O, Sommer BP, Mogk S, Duszenko M, Betzel C, Schneider TR, Chapman HN, Redecke L. Gati C, et al. Among authors: mogk s. IUCrJ. 2014 Feb 10;1(Pt 2):87-94. doi: 10.1107/S2052252513033939. eCollection 2014 Mar 1. IUCrJ. 2014. PMID: 25075324 Free PMC article.
Drug development against sleeping sickness: old wine in new bottles?
Stein J, Mogk S, Mudogo CN, Sommer BP, Scholze M, Meiwes A, Huber M, Gray A, Duszenko M. Stein J, et al. Among authors: mogk s. Curr Med Chem. 2014;21(15):1713-27. doi: 10.2174/0929867320666131119121636. Curr Med Chem. 2014. PMID: 24251577 Review.
Late stage infection in sleeping sickness.
Wolburg H, Mogk S, Acker S, Frey C, Meinert M, Schönfeld C, Lazarus M, Urade Y, Kubata BK, Duszenko M. Wolburg H, et al. Among authors: mogk s. PLoS One. 2012;7(3):e34304. doi: 10.1371/journal.pone.0034304. Epub 2012 Mar 27. PLoS One. 2012. PMID: 22496723 Free PMC article.
15 results