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The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.
Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR. Zheng X, et al. Among authors: moser cd. PLoS One. 2012;7(11):e49581. doi: 10.1371/journal.pone.0049581. Epub 2012 Nov 19. PLoS One. 2012. PMID: 23185371 Free PMC article.
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.
Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK, Guerrero RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Shire AM, Nagorney DM, Sanderson SO, Adjei AA, Lee JS, Thorgeirsson SS, Roberts LR. Lai JP, et al. Among authors: moser cd. Hepatology. 2008 Apr;47(4):1211-22. doi: 10.1002/hep.22202. Hepatology. 2008. PMID: 18318435 Free PMC article.
The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
Aderca I, Moser CD, Veerasamy M, Bani-Hani AH, Bonilla-Guerrero R, Ahmed K, Shire A, Cazanave SC, Montoya DP, Mettler TA, Burgart LJ, Nagorney DM, Thibodeau SN, Cunningham JM, Lai JP, Roberts LR. Aderca I, et al. Among authors: moser cd. J Hepatol. 2008 Sep;49(3):373-83. doi: 10.1016/j.jhep.2008.05.015. Epub 2008 Jun 9. J Hepatol. 2008. PMID: 18620777 Free PMC article.
The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation.
Lai JP, Oseini AM, Moser CD, Yu C, Elsawa SF, Hu C, Nakamura I, Han T, Aderca I, Isomoto H, Garrity-Park MM, Shire AM, Li J, Sanderson SO, Adjei AA, Fernandez-Zapico ME, Roberts LR. Lai JP, et al. Among authors: moser cd. Hepatology. 2010 Nov;52(5):1680-9. doi: 10.1002/hep.23848. Hepatology. 2010. PMID: 20725905 Free PMC article.
The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling.
Zheng X, Gai X, Han S, Moser CD, Hu C, Shire AM, Floyd RA, Roberts LR. Zheng X, et al. Among authors: moser cd. Genes Chromosomes Cancer. 2013 Mar;52(3):225-36. doi: 10.1002/gcc.22022. Epub 2012 Oct 29. Genes Chromosomes Cancer. 2013. PMID: 23109092 Free PMC article.
Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration.
Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SPS, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME. Nakamura I, et al. Among authors: moser cd. J Biol Chem. 2013 Jul 19;288(29):21389-21398. doi: 10.1074/jbc.M112.443440. Epub 2013 Jun 5. J Biol Chem. 2013. PMID: 23740243 Free PMC article.
105 results