Parkes K - Search Results

1

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.

Kesteleyn B, Amssoms K, Schepens W, Hache G, Verschueren W, Van De Vreken W, Rombauts K, Meurs G, Sterkens P, Stoops B, Baert L, Austin N, Wegner J, Masungi C, Dierynck I, Lundgren S, Jönsson D, Parkes K, Kalayanov G, Wallberg H, Rosenquist A, Samuelsson B, Van Emelen K, Thuring JW. Kesteleyn B, et al. Among authors: parkes k. Bioorg Med Chem Lett. 2013 Jan 1;23(1):310-7. doi: 10.1016/j.bmcl.2012.10.095. Epub 2012 Nov 1. Bioorg Med Chem Lett. 2013. PMID: 23177258

2

Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors.

Adrian Meredith J, Wallberg H, Vrang L, Oscarson S, Parkes K, Hallberg A, Samuelsson B. Adrian Meredith J, et al. Among authors: parkes k. Eur J Med Chem. 2010 Jan;45(1):160-70. doi: 10.1016/j.ejmech.2009.09.038. Epub 2009 Oct 6. Eur J Med Chem. 2010. PMID: 19926360

3

Discovery of USP7 small-molecule allosteric inhibitors.

Engström O, Belda O, Kullman-Magnusson M, Rapp M, Böhm K, Paul R, Henderson I, Derbyshire D, Karlström S, Parkes KEB, Zhao H. Engström O, et al. Among authors: parkes keb. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127471. doi: 10.1016/j.bmcl.2020.127471. Epub 2020 Aug 8. Bioorg Med Chem Lett. 2020. PMID: 32781219

4

Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.

Parkes KE, Ermert P, Fässler J, Ives J, Martin JA, Merrett JH, Obrecht D, Williams G, Klumpp K. Parkes KE, et al. J Med Chem. 2003 Mar 27;46(7):1153-64. doi: 10.1021/jm020334u. J Med Chem. 2003. PMID: 12646026

5

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1).

Martin JA, Bushnell DJ, Duncan IB, Dunsdon SJ, Hall MJ, Machin PJ, Merrett JH, Parkes KE, Roberts NA, Thomas GJ, et al. Martin JA, et al. Among authors: parkes ke. J Med Chem. 1990 Aug;33(8):2137-45. doi: 10.1021/jm00170a015. J Med Chem. 1990. PMID: 2165161

6

Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.

Martin JA, Lambert RW, Merrett JH, Parkes KE, Thomas GJ, Baker SJ, Bushnell DJ, Cansfield JE, Dunsdon SJ, Freeman AC, Hopkins RA, Johns IR, Keech E, Simmonite H, Walmsley A, Wong Kai-In P, Holland M. Martin JA, et al. Among authors: parkes ke. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1655-8. doi: 10.1016/s0960-894x(01)00256-6. Bioorg Med Chem Lett. 2001. PMID: 11425530

7

Confident application of a global human liver microsomal activity QSAR.

Stålring J, Sohlenius-Sternbeck AK, Terelius Y, Parkes K. Stålring J, et al. Among authors: parkes k. Future Med Chem. 2018 Jul 1;10(13):1575-1588. doi: 10.4155/fmc-2017-0323. Epub 2018 Jun 28. Future Med Chem. 2018. PMID: 29953260

8

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.

Klumpp K, Hang JQ, Rajendran S, Yang Y, Derosier A, Wong Kai In P, Overton H, Parkes KE, Cammack N, Martin JA. Klumpp K, et al. Among authors: parkes ke. Nucleic Acids Res. 2003 Dec 1;31(23):6852-9. doi: 10.1093/nar/gkg881. Nucleic Acids Res. 2003. PMID: 14627818 Free PMC article.

9

Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides.

Hang JQ, Rajendran S, Yang Y, Li Y, In PW, Overton H, Parkes KE, Cammack N, Martin JA, Klumpp K. Hang JQ, et al. Among authors: parkes ke. Biochem Biophys Res Commun. 2004 Apr 30;317(2):321-9. doi: 10.1016/j.bbrc.2004.03.061. Biochem Biophys Res Commun. 2004. PMID: 15063760

10

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.

Simmen KA, Newell A, Robinson M, Mills JS, Canning G, Handa R, Parkes K, Borkakoti N, Jupp R. Simmen KA, et al. Among authors: parkes k. J Virol. 1997 May;71(5):3886-94. doi: 10.1128/JVI.71.5.3886-3894.1997. J Virol. 1997. PMID: 9094665 Free PMC article.

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