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Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors.
Marchais-Oberwinkler S, Frotscher M, Ziegler E, Werth R, Kruchten P, Messinger J, Thole H, Hartmann RW. Marchais-Oberwinkler S, et al. Among authors: messinger j. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):205-11. doi: 10.1016/j.mce.2008.09.024. Epub 2008 Oct 4. Mol Cell Endocrinol. 2009. PMID: 18950679
New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Messinger J, Hirvelä L, Husen B, Kangas L, Koskimies P, Pentikäinen O, Saarenketo P, Thole H. Messinger J, et al. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):192-8. doi: 10.1016/j.mce.2005.11.044. Epub 2006 Jan 18. Mol Cell Endocrinol. 2006. PMID: 16413669
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Frotscher M, Ziegler E, Marchais-Oberwinkler S, Kruchten P, Neugebauer A, Fetzer L, Scherer C, Müller-Vieira U, Messinger J, Thole H, Hartmann RW. Frotscher M, et al. Among authors: messinger j. J Med Chem. 2008 Apr 10;51(7):2158-69. doi: 10.1021/jm701447v. Epub 2008 Mar 7. J Med Chem. 2008. PMID: 18324762
289 results