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Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.
Remsing LL, Garcia-Bernardo J, Gonzalez A, Künzel E, Rix U, Braña AF, Bearden DW, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: rohr j. J Am Chem Soc. 2002 Feb 27;124(8):1606-14. doi: 10.1021/ja0105156. J Am Chem Soc. 2002. PMID: 11853433 Free PMC article.
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
Remsing LL, González AM, Nur-e-Alam M, Fernández-Lozano MJ, Braña AF, Rix U, Oliveira MA, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: rohr j. J Am Chem Soc. 2003 May 14;125(19):5745-53. doi: 10.1021/ja034162h. J Am Chem Soc. 2003. PMID: 12733914 Free PMC article.
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).
Baig I, Kharel M, Kobylyanskyy A, Zhu L, Rebets Y, Ostash B, Luzhetskyy A, Bechthold A, Fedorenko VA, Rohr J. Baig I, et al. Among authors: rohr j. Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7842-6. doi: 10.1002/anie.200603176. Angew Chem Int Ed Engl. 2006. PMID: 17061307 Free PMC article. No abstract available.
576 results