Wang Y - Search Results

1

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.

Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ. Zeng LF, et al. Among authors: wang y. J Med Chem. 2012 Nov 26;55(22):9492-509. doi: 10.1021/jm300667v. Epub 2012 Nov 7. J Med Chem. 2012. PMID: 23098137

2

Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.

Wang Y, Xu ZL, Ai J, Peng X, Lin JP, Ji YC, Geng MY, Long YQ. Wang Y, et al. Org Biomol Chem. 2013 Mar 7;11(9):1545-62. doi: 10.1039/c2ob26710a. Org Biomol Chem. 2013. PMID: 23188156

3

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.

Cao B, Wang Y, Ding K, Neamati N, Long YQ. Cao B, et al. Among authors: wang y. Org Biomol Chem. 2012 Feb 14;10(6):1239-45. doi: 10.1039/c1ob06773g. Epub 2011 Dec 19. Org Biomol Chem. 2012. PMID: 22179573

4

Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.

Han X, Song N, Saidahmatov A, Wang P, Wang Y, Hu X, Kan W, Zhu W, Gao L, Zeng M, Wang Y, Li C, Li J, Liu H, Zhou Y, Wang J. Han X, et al. Among authors: wang j, wang y, wang p. J Med Chem. 2021 Oct 14;64(19):14647-14663. doi: 10.1021/acs.jmedchem.1c01148. Epub 2021 Sep 3. J Med Chem. 2021. PMID: 34477384

5

Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.

Wang Y, Lu H, Zhu Q, Jiang S, Liao Y. Wang Y, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):189-92. doi: 10.1016/j.bmcl.2009.10.139. Epub 2009 Nov 5. Bioorg Med Chem Lett. 2010. PMID: 19932616 Free PMC article.

6

Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element.

Wang Y, Sun X, Yang D, Guo Z, Fan X, Nie M, Zhang F, Liu Y, Li Y, Wang Y, Gong P, Liu Y. Wang Y, et al. Bioorg Med Chem. 2016 Nov 1;24(21):5646-5661. doi: 10.1016/j.bmc.2016.09.024. Epub 2016 Sep 12. Bioorg Med Chem. 2016. PMID: 27663548

7

Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity.

Sun X, Hong Z, Liu M, Guo S, Yang D, Wang Y, Lan T, Gao L, Qi H, Gong P, Liu Y. Sun X, et al. Among authors: wang y. Bioorg Med Chem. 2017 May 15;25(10):2800-2810. doi: 10.1016/j.bmc.2017.03.055. Epub 2017 Mar 29. Bioorg Med Chem. 2017. PMID: 28389110

8

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.

Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC. Dewdney TG, et al. Among authors: wang y. Bioorg Med Chem. 2013 Dec 1;21(23):7430-4. doi: 10.1016/j.bmc.2013.09.045. Epub 2013 Sep 27. Bioorg Med Chem. 2013. PMID: 24128815

9

Halogen bonding--a novel interaction for rational drug design?

Lu Y, Shi T, Wang Y, Yang H, Yan X, Luo X, Jiang H, Zhu W. Lu Y, et al. Among authors: wang y. J Med Chem. 2009 May 14;52(9):2854-62. doi: 10.1021/jm9000133. J Med Chem. 2009. PMID: 19358610

10

Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.

Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM. Ward YD, et al. Among authors: wang y. J Med Chem. 2002 Dec 5;45(25):5471-82. doi: 10.1021/jm020209i. J Med Chem. 2002. PMID: 12459015

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