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Page 1
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.
Dockendorff C, Nagiec MM, Weïwer M, Buhrlage S, Ting A, Nag PP, Germain A, Kim HJ, Youngsaye W, Scherer C, Bennion M, Xue L, Stanton BZ, Lewis TA, Macpherson L, Palmer M, Foley MA, Perez JR, Schreiber SL. Dockendorff C, et al. Among authors: foley ma. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813. doi: 10.1021/ml300172p. Epub 2012 Aug 30. ACS Med Chem Lett. 2012. PMID: 23074541 Free PMC article.
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. Dandapani S, et al. Among authors: foley m. ACS Med Chem Lett. 2013 Dec 29;5(2):149-53. doi: 10.1021/ml400403u. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900788 Free PMC article.
Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.
Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL. Comer E, et al. Among authors: foley ma. J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. Epub 2014 Oct 13. J Med Chem. 2014. PMID: 25211597 Free PMC article.
Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.
Lukens AK, Heidebrecht RW Jr, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, Wirth DF. Lukens AK, et al. J Infect Dis. 2015 Apr 1;211(7):1097-103. doi: 10.1093/infdis/jiu565. Epub 2014 Oct 21. J Infect Dis. 2015. PMID: 25336726 Free PMC article.
Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
Nagiec MM, Skepner AP, Negri J, Eichhorn M, Kuperwasser N, Comer E, Muncipinto G, Subramanian A, Clish C, Musunuru K, Duvall JR, Foley M, Perez JR, Palmer MA. Nagiec MM, et al. Among authors: foley m. PLoS One. 2015 Mar 26;10(3):e0120295. doi: 10.1371/journal.pone.0120295. eCollection 2015. PLoS One. 2015. PMID: 25811180 Free PMC article.
Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.
Nagiec MM, Duvall JR, Skepner AP, Howe EA, Bastien J, Comer E, Marie JC, Johnston SE, Negri J, Eichhorn M, Vantourout J, Clish C, Musunuru K, Foley M, Perez JR, Palmer MAJ. Nagiec MM, et al. Medchemcomm. 2018 Sep 14;9(11):1831-1842. doi: 10.1039/c8md00297e. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30542533 Free PMC article.
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
Duvall JR, Bedard L, Naylor-Olsen AM, Manson AL, Bittker JA, Sun W, Fitzgerald ME, He Z, Lee MD 4th, Marie JC, Muncipinto G, Rush D, Xu D, Xu H, Zhang M, Earl AM, Palmer MA, Foley MA, Vacca JP, Scherer CA. Duvall JR, et al. Among authors: foley ma. ACS Infect Dis. 2017 May 12;3(5):349-359. doi: 10.1021/acsinfecdis.6b00206. Epub 2017 Mar 7. ACS Infect Dis. 2017. PMID: 28215073 Free PMC article.
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.
Heidebrecht RW Jr, Mulrooney C, Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, Hinkson P, Kramer M, Lukens AK, Masi D, Marcaurelle LA, Su XZ, Thomas CJ, Weïwer M, Wiegand RC, Wirth D, Xia M, Yuan J, Zhao J, Palmer M, Munoz B, Schreiber S. Heidebrecht RW Jr, et al. ACS Med Chem Lett. 2012 Feb 9;3(2):112-117. doi: 10.1021/ml200244k. Epub 2011 Dec 22. ACS Med Chem Lett. 2012. PMID: 22328964 Free PMC article.
105 results