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Black mamba venom peptides target acid-sensing ion channels to abolish pain.
Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay AS, Debayle D, Friend V, Alloui A, Lazdunski M, Lingueglia E. Diochot S, et al. Among authors: douguet d. Nature. 2012 Oct 25;490(7421):552-5. doi: 10.1038/nature11494. Epub 2012 Oct 3. Nature. 2012. PMID: 23034652 Free article.
Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D. Mourier G, et al. Among authors: douguet d. J Biol Chem. 2016 Feb 5;291(6):2616-29. doi: 10.1074/jbc.M115.702373. Epub 2015 Dec 17. J Biol Chem. 2016. PMID: 26680001 Free PMC article.
TWIK1, a unique background channel with variable ion selectivity.
Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F. Chatelain FC, et al. Among authors: douguet d. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5499-504. doi: 10.1073/pnas.1201132109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431633 Free PMC article.
Piezo Ion Channels in Cardiovascular Mechanobiology.
Douguet D, Patel A, Xu A, Vanhoutte PM, Honoré E. Douguet D, et al. Trends Pharmacol Sci. 2019 Dec;40(12):956-970. doi: 10.1016/j.tips.2019.10.002. Epub 2019 Nov 5. Trends Pharmacol Sci. 2019. PMID: 31704174 Review.
Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma.
Signetti L, Elizarov N, Simsir M, Paquet A, Douguet D, Labbal F, Debayle D, Di Giorgio A, Biou V, Girard C, Duca M, Bretillon L, Bertolotto C, Verrier B, Azoulay S, Mus-Veteau I. Signetti L, et al. Among authors: douguet d. Cancers (Basel). 2020 Jun 9;12(6):1500. doi: 10.3390/cancers12061500. Cancers (Basel). 2020. PMID: 32526884 Free PMC article.
67 results