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A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S. Opsenica I, et al. Among authors: bavari s. J Med Chem. 2011 Mar 10;54(5):1157-69. doi: 10.1021/jm100938u. Epub 2011 Jan 25. J Med Chem. 2011. PMID: 21265542 Free PMC article.
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
Videnović M, Opsenica DM, Burnett JC, Gomba L, Nuss JE, Selaković Z, Konstantinović J, Krstić M, Segan S, Zlatović M, Sciotti RJ, Bavari S, Solaja BA. Videnović M, et al. Among authors: bavari s. J Med Chem. 2014 May 22;57(10):4134-53. doi: 10.1021/jm500033r. Epub 2014 May 1. J Med Chem. 2014. PMID: 24742203 Free PMC article.
Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action.
Selaković Ž, Tran JP, Kota KP, Lazić M, Retterer C, Besch R, Panchal RG, Soloveva V, Sean VA, Jay WB, Pavić A, Verbić T, Vasiljević B, Kuehl K, Duplantier AJ, Bavari S, Mudhasani R, Šolaja BA. Selaković Ž, et al. Among authors: bavari s. Eur J Med Chem. 2019 Jan 15;162:32-50. doi: 10.1016/j.ejmech.2018.10.061. Epub 2018 Oct 31. Eur J Med Chem. 2019. PMID: 30408747
Molecular mechanisms of filovirus cellular trafficking.
Aman MJ, Bosio CM, Panchal RG, Burnett JC, Schmaljohn A, Bavari S. Aman MJ, et al. Among authors: bavari s. Microbes Infect. 2003 Jun;5(7):639-49. doi: 10.1016/s1286-4579(03)00095-9. Microbes Infect. 2003. PMID: 12787740 Free article. Review.
322 results