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Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Clin Cancer Res. 2012 Dec 15;18(24):6623-33. doi: 10.1158/1078-0432.CCR-12-0861. Epub 2012 Aug 24.
Clin Cancer Res. 2012.
PMID: 22923450
Free PMC article.
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG.
Tan C, et al. Among authors: de noronha rg.
Cancer Res. 2005 Jan 15;65(2):605-12.
Cancer Res. 2005.
PMID: 15695405
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Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.
Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG.
Tan C, et al. Among authors: de noronha rg.
Bioorg Med Chem Lett. 2011 Sep 15;21(18):5528-32. doi: 10.1016/j.bmcl.2011.06.099. Epub 2011 Jun 28.
Bioorg Med Chem Lett. 2011.
PMID: 21831638
Free PMC article.
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Total synthesis and biological evaluation of halipeptins A and D and analogues.
Nicolaou KC, Lizos DE, Kim DW, Schlawe D, de Noronha RG, Longbottom DA, Rodriquez M, Bucci M, Cirino G.
Nicolaou KC, et al. Among authors: de noronha rg.
J Am Chem Soc. 2006 Apr 5;128(13):4460-70. doi: 10.1021/ja060064v.
J Am Chem Soc. 2006.
PMID: 16569024
Item in Clipboard
Total synthesis of halipeptins A and D and analogues.
Nicolaou KC, Kim DW, Schlawe D, Lizos DE, de Noronha RG, Longbottom DA.
Nicolaou KC, et al. Among authors: de noronha rg.
Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4925-9. doi: 10.1002/anie.200500702.
Angew Chem Int Ed Engl. 2005.
PMID: 16010700
No abstract available.
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Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.
Nicolaou KC, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ.
Nicolaou KC, et al. Among authors: de noronha rg.
Chemistry. 2005 Oct 21;11(21):6197-211. doi: 10.1002/chem.200500624.
Chemistry. 2005.
PMID: 16075448
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Highly chemo- and regioselective reduction of aromatic nitro compounds using the system silane/oxo-rhenium complexes.
de Noronha RG, Romão CC, Fernandes AC.
de Noronha RG, et al.
J Org Chem. 2009 Sep 18;74(18):6960-4. doi: 10.1021/jo9008657.
J Org Chem. 2009.
PMID: 19685891
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