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Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou KC, Van Meir EG. Yin S, et al. Among authors: jabbar aa. Clin Cancer Res. 2012 Dec 15;18(24):6623-33. doi: 10.1158/1078-0432.CCR-12-0861. Epub 2012 Aug 24. Clin Cancer Res. 2012. PMID: 22923450 Free PMC article.
Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.
Mun J, Jabbar AA, Devi NS, Liu Y, Van Meir EG, Goodman MM. Mun J, et al. Among authors: jabbar aa. Bioorg Med Chem. 2012 Jul 15;20(14):4590-7. doi: 10.1016/j.bmc.2012.04.064. Epub 2012 May 14. Bioorg Med Chem. 2012. PMID: 22682301 Free PMC article.
Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.
Mun J, Jabbar AA, Devi NS, Yin S, Wang Y, Tan C, Culver D, Snyder JP, Van Meir EG, Goodman MM. Mun J, et al. Among authors: jabbar aa. J Med Chem. 2012 Aug 9;55(15):6738-50. doi: 10.1021/jm300752n. Epub 2012 Jul 24. J Med Chem. 2012. PMID: 22746274 Free PMC article.
Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.
Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG. Tan C, et al. Among authors: jabbar aa. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5528-32. doi: 10.1016/j.bmcl.2011.06.099. Epub 2011 Jun 28. Bioorg Med Chem Lett. 2011. PMID: 21831638 Free PMC article.
National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma.
Dar FS, Abbas Z, Ahmed I, Atique M, Aujla UI, Azeemuddin M, Aziz Z, Bhatti ABH, Bangash TA, Butt AS, Butt OT, Dogar AW, Farooqi JI, Hanif F, Haider J, Haider S, Hassan SM, Jabbar AA, Khan AN, Khan MS, Khan MY, Latif A, Luck NH, Malik AK, Rashid K, Rashid S, Salih M, Saeed A, Salamat A, Tayyab GU, Yusuf A, Zia HH, Naveed A. Dar FS, et al. Among authors: jabbar aa. World J Gastroenterol. 2024 Mar 7;30(9):1018-1042. doi: 10.3748/wjg.v30.i9.1018. World J Gastroenterol. 2024. PMID: 38577184 Free PMC article. Review.
Mangiferin (mango) attenuates AOM-induced colorectal cancer in rat's colon by augmentation of apoptotic proteins and antioxidant mechanisms.
Abdul-Aziz Ahmed K, Jabbar AAJ, Abdulla MA, Zuhair Alamri Z, Ain Salehen N, Abdel Aziz Ibrahim I, Almaimani G, Bamagous GA, Almaimani RA, Almasmoum HA, Ghaith MM, Farrash WF. Abdul-Aziz Ahmed K, et al. Among authors: jabbar aaj. Sci Rep. 2024 Jan 8;14(1):813. doi: 10.1038/s41598-023-50947-y. Sci Rep. 2024. PMID: 38191592 Free PMC article.
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