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Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou KC, Van Meir EG. Yin S, et al. Among authors: devi ns. Clin Cancer Res. 2012 Dec 15;18(24):6623-33. doi: 10.1158/1078-0432.CCR-12-0861. Epub 2012 Aug 24. Clin Cancer Res. 2012. PMID: 22923450 Free PMC article.
Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.
Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG. Kaur B, et al. Among authors: devi ns. Cancer Res. 2009 Feb 1;69(3):1212-20. doi: 10.1158/0008-5472.CAN-08-1166. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176395 Free PMC article.
Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.
Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG. Tan C, et al. Among authors: devi ns. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5528-32. doi: 10.1016/j.bmcl.2011.06.099. Epub 2011 Jun 28. Bioorg Med Chem Lett. 2011. PMID: 21831638 Free PMC article.
Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.
Mun J, Jabbar AA, Devi NS, Liu Y, Van Meir EG, Goodman MM. Mun J, et al. Among authors: devi ns. Bioorg Med Chem. 2012 Jul 15;20(14):4590-7. doi: 10.1016/j.bmc.2012.04.064. Epub 2012 May 14. Bioorg Med Chem. 2012. PMID: 22682301 Free PMC article.
54 results