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Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.
Mittendorf J, Weigand S, Alonso-Alija C, Bischoff E, Feurer A, Gerisch M, Kern A, Knorr A, Lang D, Muenter K, Radtke M, Schirok H, Schlemmer KH, Stahl E, Straub A, Wunder F, Stasch JP. Mittendorf J, et al. Among authors: stasch jp. ChemMedChem. 2009 May;4(5):853-65. doi: 10.1002/cmdc.200900014. ChemMedChem. 2009. PMID: 19263460 Free article.
Riociguat for the treatment of pulmonary hypertension.
Schermuly RT, Janssen W, Weissmann N, Stasch JP, Grimminger F, Ghofrani HA. Schermuly RT, et al. Among authors: stasch jp. Expert Opin Investig Drugs. 2011 Apr;20(4):567-76. doi: 10.1517/13543784.2011.565048. Epub 2011 Mar 11. Expert Opin Investig Drugs. 2011. PMID: 21391889 Review.
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
Chester M, Seedorf G, Tourneux P, Gien J, Tseng N, Grover T, Wright J, Stasch JP, Abman SH. Chester M, et al. Among authors: stasch jp. Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L755-64. doi: 10.1152/ajplung.00138.2010. Epub 2011 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 21856817 Free PMC article.
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