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Page 1
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC; Sanger Institute Mouse Genetics Project; Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. White JK, et al. Cell. 2013 Jul 18;154(2):452-64. doi: 10.1016/j.cell.2013.06.022. Cell. 2013. PMID: 23870131 Free PMC article.
Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project; O'Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Novoselova TV, et al. Among authors: wynn eh. J Endocrinol. 2016 Jul;230(1):13-26. doi: 10.1530/JOE-16-0057. Epub 2016 Apr 22. J Endocrinol. 2016. PMID: 27106110 Free PMC article.
Pathogenicity and selective constraint on variation near splice sites.
Lord J, Gallone G, Short PJ, McRae JF, Ironfield H, Wynn EH, Gerety SS, He L, Kerr B, Johnson DS, McCann E, Kinning E, Flinter F, Temple IK, Clayton-Smith J, McEntagart M, Lynch SA, Joss S, Douzgou S, Dabir T, Clowes V, McConnell VPM, Lam W, Wright CF, FitzPatrick DR, Firth HV, Barrett JC, Hurles ME; Deciphering Developmental Disorders study. Lord J, et al. Among authors: wynn eh. Genome Res. 2019 Feb;29(2):159-170. doi: 10.1101/gr.238444.118. Epub 2018 Dec 26. Genome Res. 2019. PMID: 30587507 Free PMC article.
Lyplal1 is dispensable for normal fat deposition in mice.
Watson RA, Gates AS, Wynn EH, Calvert FE, Girousse A, Lelliott CJ, Barroso I. Watson RA, et al. Among authors: wynn eh. Dis Model Mech. 2017 Dec 19;10(12):1481-1488. doi: 10.1242/dmm.031864. Dis Model Mech. 2017. PMID: 29084768 Free PMC article.