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Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells.
Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC, Waisman A. Yogev N, et al. Among authors: reizis b. Immunity. 2012 Aug 24;37(2):264-75. doi: 10.1016/j.immuni.2012.05.025. Epub 2012 Aug 16. Immunity. 2012. PMID: 22902234 Free article.
Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome.
Birnberg T, Bar-On L, Sapoznikov A, Caton ML, Cervantes-Barragán L, Makia D, Krauthgamer R, Brenner O, Ludewig B, Brockschnieder D, Riethmacher D, Reizis B, Jung S. Birnberg T, et al. Among authors: reizis b. Immunity. 2008 Dec 19;29(6):986-97. doi: 10.1016/j.immuni.2008.10.012. Epub 2008 Dec 8. Immunity. 2008. PMID: 19062318 Free article.
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.
Kool M, van Loo G, Waelput W, De Prijck S, Muskens F, Sze M, van Praet J, Branco-Madeira F, Janssens S, Reizis B, Elewaut D, Beyaert R, Hammad H, Lambrecht BN. Kool M, et al. Among authors: reizis b. Immunity. 2011 Jul 22;35(1):82-96. doi: 10.1016/j.immuni.2011.05.013. Epub 2011 Jun 30. Immunity. 2011. PMID: 21723156 Free article.
127 results