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D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis.
Apoptosis. 2012 Oct;17(10):1079-94. doi: 10.1007/s10495-012-0746-x.
Apoptosis. 2012.
PMID: 22843330
Free PMC article.
The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis.
Cabello CM, Lamore SD, Bair WB 3rd, Qiao S, Azimian S, Lesson JL, Wondrak GT.
Cabello CM, et al. Among authors: lesson jl.
Invest New Drugs. 2012 Aug;30(4):1289-301. doi: 10.1007/s10637-011-9676-7. Epub 2011 May 6.
Invest New Drugs. 2012.
PMID: 21547369
Free PMC article.
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Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.
Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.
Qiao S, et al. Among authors: lesson jl.
Biochem Pharmacol. 2012 May 1;83(9):1229-40. doi: 10.1016/j.bcp.2012.01.027. Epub 2012 Feb 1.
Biochem Pharmacol. 2012.
PMID: 22321511
Free PMC article.
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The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.
Davis AL, Qiao S, Lesson JL, Rojo de la Vega M, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT.
Davis AL, et al. Among authors: lesson jl.
J Biol Chem. 2015 Jan 16;290(3):1623-38. doi: 10.1074/jbc.M114.592626. Epub 2014 Dec 4.
J Biol Chem. 2015.
PMID: 25477506
Free PMC article.
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The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis.
Justiniano R, Williams JD, Perer J, Hua A, Lesson J, Park SL, Wondrak GT.
Justiniano R, et al.
Photochem Photobiol. 2017 Jul;93(4):990-998. doi: 10.1111/php.12720. Epub 2017 Feb 28.
Photochem Photobiol. 2017.
PMID: 28083878
Free PMC article.
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