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Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.
Orellana R, Kato S, Erices R, Bravo ML, Gonzalez P, Oliva B, Cubillos S, Valdivia A, Ibañez C, Brañes J, Barriga MI, Bravo E, Alonso C, Bustamente E, Castellon E, Hidalgo P, Trigo C, Panes O, Pereira J, Mezzano D, Cuello MA, Owen GI. Orellana R, et al. BMC Cancer. 2015 Apr 15;15:290. doi: 10.1186/s12885-015-1304-z. BMC Cancer. 2015. PMID: 25886038 Free PMC article.
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.
Erices R, Cubillos S, Aravena R, Santoro F, Marquez M, Orellana R, Ramírez C, González P, Fuenzalida P, Bravo ML, Oliva B, Kato S, Ibañez C, Brañes J, Bravo E, Alonso C, García K, Arab C, Torres VA, Godoy AS, Pereira J, Bustos G, Cardenas JC, Cuello MA, Owen GI. Erices R, et al. Oncotarget. 2017 Mar 28;8(13):20865-20880. doi: 10.18632/oncotarget.15348. Oncotarget. 2017. PMID: 28209916 Free PMC article.
26 results