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A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.
Zhang HS, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, Su H, Jovin IS, Kunis M, Hinkley S, Liang Y, Hinh L, Spratt SK, Case CC, Rebar EJ, Ehrlich BE, Ehrlich B, Gregory PD, Giordano FJ. Zhang HS, et al. Among authors: spratt sk. Mol Ther. 2012 Aug;20(8):1508-15. doi: 10.1038/mt.2012.80. Epub 2012 Jul 24. Mol Ther. 2012. PMID: 22828502 Free PMC article.
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.
Tan S, Guschin D, Davalos A, Lee YL, Snowden AW, Jouvenot Y, Zhang HS, Howes K, McNamara AR, Lai A, Ullman C, Reynolds L, Moore M, Isalan M, Berg LP, Campos B, Qi H, Spratt SK, Case CC, Pabo CO, Campisi J, Gregory PD. Tan S, et al. Among authors: spratt sk. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):11997-2002. doi: 10.1073/pnas.2035056100. Epub 2003 Sep 26. Proc Natl Acad Sci U S A. 2003. PMID: 14514889 Free PMC article.
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.
Liu PQ, Rebar EJ, Zhang L, Liu Q, Jamieson AC, Liang Y, Qi H, Li PX, Chen B, Mendel MC, Zhong X, Lee YL, Eisenberg SP, Spratt SK, Case CC, Wolffe AP. Liu PQ, et al. Among authors: spratt sk. J Biol Chem. 2001 Apr 6;276(14):11323-34. doi: 10.1074/jbc.M011172200. Epub 2001 Jan 5. J Biol Chem. 2001. PMID: 11145970 Free article.
Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
Dai Q, Huang J, Klitzman B, Dong C, Goldschmidt-Clermont PJ, March KL, Rokovich J, Johnstone B, Rebar EJ, Spratt SK, Case CC, Kontos CD, Annex BH. Dai Q, et al. Among authors: spratt sk. Circulation. 2004 Oct 19;110(16):2467-75. doi: 10.1161/01.CIR.0000145139.53840.49. Epub 2004 Oct 11. Circulation. 2004. PMID: 15477407
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, Spratt SK, Surosky RT, Giedlin MA, Nichol G, Holmes MC, Gregory PD, Ando DG, Kalos M, Collman RG, Binder-Scholl G, Plesa G, Hwang WT, Levine BL, June CH. Tebas P, et al. Among authors: spratt sk. N Engl J Med. 2014 Mar 6;370(10):901-10. doi: 10.1056/NEJMoa1300662. N Engl J Med. 2014. PMID: 24597865 Free PMC article. Clinical Trial.
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.
Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, Zheng Z, Cotte J, Carpenito C, Wood T, Spratt SK, Ando D, Gregory P, Holmes MC, Perez EE, Riley JL, Carroll RG, June CH, Levine BL. Maier DA, et al. Among authors: spratt sk. Hum Gene Ther. 2013 Mar;24(3):245-58. doi: 10.1089/hum.2012.172. Epub 2013 Mar 6. Hum Gene Ther. 2013. PMID: 23360514 Free PMC article.
37 results