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A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.
Zhang HS, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, Su H, Jovin IS, Kunis M, Hinkley S, Liang Y, Hinh L, Spratt SK, Case CC, Rebar EJ, Ehrlich BE, Ehrlich B, Gregory PD, Giordano FJ. Zhang HS, et al. Among authors: huang y. Mol Ther. 2012 Aug;20(8):1508-15. doi: 10.1038/mt.2012.80. Epub 2012 Jul 24. Mol Ther. 2012. PMID: 22828502 Free PMC article.
Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis.
Zhang P, Huang A, Morales-Ruiz M, Starcher BC, Huang Y, Sessa WC, Niklason LE, Giordano FJ. Zhang P, et al. Among authors: huang a, huang y. Hum Gene Ther. 2012 Nov;23(11):1186-99. doi: 10.1089/hum.2011.201. Hum Gene Ther. 2012. PMID: 22891920 Free PMC article.
Cellular endocytosis and gene delivery.
Ziello JE, Huang Y, Jovin IS. Ziello JE, et al. Among authors: huang y. Mol Med. 2010 May-Jun;16(5-6):222-9. doi: 10.2119/molmed.2009.00101. Epub 2010 Feb 3. Mol Med. 2010. PMID: 20454523 Free PMC article. Review.
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