O'Neill C - Search Results

1

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

O'Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM. O'Neill C, et al. Biochem Soc Trans. 2012 Aug;40(4):721-7. doi: 10.1042/BST20120080. Biochem Soc Trans. 2012. PMID: 22817723 Review.

2

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.

Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C. Griffin RJ, et al. J Neurochem. 2005 Apr;93(1):105-17. doi: 10.1111/j.1471-4159.2004.02949.x. J Neurochem. 2005. PMID: 15773910 Free article.

3

Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.

Stockley JH, Ravid R, O'Neill C. Stockley JH, et al. FEBS Lett. 2006 Dec 11;580(28-29):6550-60. doi: 10.1016/j.febslet.2006.10.076. Epub 2006 Nov 13. FEBS Lett. 2006. PMID: 17113083 Free article.

4

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling.

Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, O'Neill C. Moloney AM, et al. Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Neurobiol Aging. 2010. PMID: 18479783

5

Akt signal transduction dysfunction in Parkinson's disease.

Timmons S, Coakley MF, Moloney AM, O' Neill C. Timmons S, et al. Neurosci Lett. 2009 Dec 18;467(1):30-5. doi: 10.1016/j.neulet.2009.09.055. Epub 2009 Oct 1. Neurosci Lett. 2009. PMID: 19800394

6

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

Long-Smith CM, Manning S, McClean PL, Coakley MF, O'Halloran DJ, Holscher C, O'Neill C. Long-Smith CM, et al. Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21. Neuromolecular Med. 2013. PMID: 23011726

7

PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease.

O' Neill C. O' Neill C. Exp Gerontol. 2013 Jul;48(7):647-53. doi: 10.1016/j.exger.2013.02.025. Epub 2013 Mar 5. Exp Gerontol. 2013. PMID: 23470275 Review.

8

PINK1 signalling in cancer biology.

O'Flanagan CH, O'Neill C. O'Flanagan CH, et al. Biochim Biophys Acta. 2014 Dec;1846(2):590-8. doi: 10.1016/j.bbcan.2014.10.006. Epub 2014 Oct 23. Biochim Biophys Acta. 2014. PMID: 25450579 Review.

9

Clinical Consensus Guidelines on the Application of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Diagnosis: Recommendations of the Irish Network for Biomarkers in Neurodegeneration.

Miller AM, Begley E, Coen R, Doyle M, Dunne J, Hutchinson S, Kennelly SP, Kenny RA, Killeen RP, Lynch A, O'Dwyer S, O'Neill C, O'Sullvan SS, Rowan MJ, Sheehy N, McGuigan C, Lawlor BA. Miller AM, et al. Ir Med J. 2016 Dec 12;109(10):483. Ir Med J. 2016. PMID: 28644588

10

The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P₃.

Furlong RM, Lindsay A, Anderson KE, Hawkins PT, Sullivan AM, O'Neill C. Furlong RM, et al. J Cell Sci. 2019 Oct 22;132(20):jcs233221. doi: 10.1242/jcs.233221. J Cell Sci. 2019. PMID: 31540955

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