Hilgenfeld R - Search Results

1

Recent advances in neuraminidase inhibitor development as anti-influenza drugs.

Feng E, Ye D, Li J, Zhang D, Wang J, Zhao F, Hilgenfeld R, Zheng M, Jiang H, Liu H. Feng E, et al. Among authors: hilgenfeld r. ChemMedChem. 2012 Sep;7(9):1527-36. doi: 10.1002/cmdc.201200155. Epub 2012 Jul 16. ChemMedChem. 2012. PMID: 22807317 Review.

2

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.

Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H. Dai W, et al. Among authors: hilgenfeld r. J Med Chem. 2022 Feb 24;65(4):2794-2808. doi: 10.1021/acs.jmedchem.0c02258. Epub 2021 Apr 19. J Med Chem. 2022. PMID: 33872498

3

Improved synthesis of rupintrivir.

Lin D, Qian W, Hilgenfeld R, Jiang H, Chen K, Liu H. Lin D, et al. Among authors: hilgenfeld r. Sci China Chem. 2012;55(6):1101-1107. doi: 10.1007/s11426-011-4478-5. Epub 2012 Jan 4. Sci China Chem. 2012. PMID: 32215000 Free PMC article.

4

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A.

Luo C, Luo H, Zheng S, Gui C, Yue L, Yu C, Sun T, He P, Chen J, Shen J, Luo X, Li Y, Liu H, Bai D, Shen J, Yang Y, Li F, Zuo J, Hilgenfeld R, Pei G, Chen K, Shen X, Jiang H. Luo C, et al. Among authors: hilgenfeld r. Biochem Biophys Res Commun. 2004 Aug 27;321(3):557-65. doi: 10.1016/j.bbrc.2004.07.003. Biochem Biophys Res Commun. 2004. PMID: 15358143 Free PMC article.

5

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Li H, Huang J, Chen L, Liu X, Chen T, Zhu J, Lu W, Shen X, Li J, Hilgenfeld R, Jiang H. Li H, et al. Among authors: hilgenfeld r. J Med Chem. 2009 Aug 13;52(15):4936-40. doi: 10.1021/jm801622x. J Med Chem. 2009. PMID: 19586036

6

Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease.

Ye F, Zhang J, Liu H, Hilgenfeld R, Zhang R, Kong X, Li L, Lu J, Zhang X, Li D, Jiang H, Yang CG, Luo C. Ye F, et al. Among authors: hilgenfeld r. J Biol Chem. 2013 Jun 14;288(24):17643-53. doi: 10.1074/jbc.M113.452714. Epub 2013 Apr 26. J Biol Chem. 2013. PMID: 23625918 Free PMC article.

7

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

van der Linden L, Ulferts R, Nabuurs SB, Kusov Y, Liu H, George S, Lacroix C, Goris N, Lefebvre D, Lanke KH, De Clercq K, Hilgenfeld R, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: hilgenfeld r. Antiviral Res. 2014 Mar;103:17-24. doi: 10.1016/j.antiviral.2013.12.012. Epub 2014 Jan 4. Antiviral Res. 2014. PMID: 24393668 Free PMC article.

8

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses.

Tan J, Verschueren KH, Anand K, Shen J, Yang M, Xu Y, Rao Z, Bigalke J, Heisen B, Mesters JR, Chen K, Shen X, Jiang H, Hilgenfeld R. Tan J, et al. Among authors: hilgenfeld r. J Mol Biol. 2005 Nov 18;354(1):25-40. doi: 10.1016/j.jmb.2005.09.012. Epub 2005 Sep 23. J Mol Biol. 2005. PMID: 16242152 Free PMC article.

9

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.

Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R. Zhang L, et al. Among authors: hilgenfeld r. J Med Chem. 2020 May 14;63(9):4562-4578. doi: 10.1021/acs.jmedchem.9b01828. Epub 2020 Feb 24. J Med Chem. 2020. PMID: 32045235

10

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.

Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R. Hansen G, et al. Among authors: hilgenfeld r. Structure. 2011 Jul 13;19(7):919-29. doi: 10.1016/j.str.2011.03.025. Structure. 2011. PMID: 21742259 Free article.

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