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Recent developments in ghrelin receptor ligands.
Moulin A, Ryan J, Martinez J, Fehrentz JA. Moulin A, et al. Among authors: martinez j. ChemMedChem. 2007 Sep;2(9):1242-59. doi: 10.1002/cmdc.200700015. ChemMedChem. 2007. PMID: 17520591 Review.
Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.
Moulin A, Demange L, Bergé G, Gagne D, Ryan J, Mousseaux D, Heitz A, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J. Moulin A, et al. Among authors: martinez j. J Med Chem. 2007 Nov 15;50(23):5790-806. doi: 10.1021/jm0704550. Epub 2007 Oct 10. J Med Chem. 2007. PMID: 17927165
New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.
Moulin A, Demange L, Ryan J, Mousseaux D, Sanchez P, Bergé G, Gagne D, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J. Moulin A, et al. Among authors: martinez j. J Med Chem. 2008 Feb 14;51(3):689-93. doi: 10.1021/jm701292s. Epub 2008 Jan 15. J Med Chem. 2008. PMID: 18193826
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.
Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA. Blayo AL, et al. Among authors: martinez j. Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15. Bioorg Med Chem Lett. 2015. PMID: 25435152
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.
M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J. M'Kadmi C, et al. Among authors: martinez j. J Biol Chem. 2015 Nov 6;290(45):27021-27039. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363071 Free PMC article.
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.
Maingot M, Blayo AL, Denoyelle S, M'Kadmi C, Damian M, Mary S, Gagne D, Sanchez P, Aicher B, Schmidt P, Müller G, Teifel M, Günther E, Marie J, Banères JL, Martinez J, Fehrentz JA. Maingot M, et al. Among authors: martinez j. Bioorg Med Chem Lett. 2016 May 15;26(10):2408-2412. doi: 10.1016/j.bmcl.2016.04.003. Epub 2016 Apr 4. Bioorg Med Chem Lett. 2016. PMID: 27072910
8,979 results