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Structural basis of biological nitrile reduction.
Chikwana VM, Stec B, Lee BW, de Crécy-Lagard V, Iwata-Reuyl D, Swairjo MA. Chikwana VM, et al. J Biol Chem. 2012 Aug 31;287(36):30560-70. doi: 10.1074/jbc.M112.388538. Epub 2012 Jul 11. J Biol Chem. 2012. PMID: 22787148 Free PMC article.
Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing.
Fortea E, Lemieux V, Potvin L, Chikwana V, Griffin S, Hey T, McCaskill D, Narva K, Tan SY, Xu X, Vachon V, Schwartz JL. Fortea E, et al. J Biol Chem. 2017 Aug 11;292(32):13122-13132. doi: 10.1074/jbc.M116.765941. Epub 2017 Jun 16. J Biol Chem. 2017. PMID: 28623231 Free PMC article.
Incorporation of phosphate into glycogen by glycogen synthase.
Contreras CJ, Segvich DM, Mahalingan K, Chikwana VM, Kirley TL, Hurley TD, DePaoli-Roach AA, Roach PJ. Contreras CJ, et al. Among authors: chikwana vm. Arch Biochem Biophys. 2016 May 1;597:21-9. doi: 10.1016/j.abb.2016.03.020. Epub 2016 Mar 29. Arch Biochem Biophys. 2016. PMID: 27036853 Free PMC article.
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
Tang B, Frasinyuk MS, Chikwana VM, Mahalingan KK, Morgan CA, Segvich DM, Bondarenko SP, Mrug GP, Wyrebek P, Watt DS, DePaoli-Roach AA, Roach PJ, Hurley TD. Tang B, et al. Among authors: chikwana vm. J Med Chem. 2020 Apr 9;63(7):3538-3551. doi: 10.1021/acs.jmedchem.9b01851. Epub 2020 Mar 23. J Med Chem. 2020. PMID: 32134266 Free PMC article.
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS. Sun RC, et al. Among authors: chikwana vm. Cell Metab. 2021 Jul 6;33(7):1404-1417.e9. doi: 10.1016/j.cmet.2021.05.003. Epub 2021 May 26. Cell Metab. 2021. PMID: 34043942 Free PMC article.
11 results